Improvement of prostaglandin-associated periorbitopathy after discontinuing treatment

Objective: To report that the periorbital changes induced by prostaglandin analogues eyedrops are partially reversible after discontinuing the treatment.
Methods: Nine patients seen in a referral oculoplastic practice with prostaglandin-associated periorbitopathy were included in this study, eight with unilateral glaucoma and one with bilateral open-angle glaucoma. All of them had been treated with topical prostaglandin analogues for at least one year, before the treatment was discontinued because of cosmetic reasons.
Results: In all cases the periocular differences between the treated eye and the fellow eye was evident, consisting mainly in deepening of the upper eyelid sulcus and eyelid fat pad reduction. One year after discontinuing the prostaglandin analogue eye-drops an improvement of features was observed.
Conclusion: Clinicians and patients should be aware of the side-effects on periorbital tissues of topical prostaglandin analogue therapy, and that these side effects can be partially reversed after discontinuation of the medication.
Keywords: periorbitopathy, prostaglandin analogue, prostaglandin-associated periorbitopathy, periorbital changes.