. 2020; 35(2): 99-105 | DOI: 10.5222/MMJ.2020.58708 | |||
Aberrant SOCS3 Promoter Methylation as a Noninvasive Diagnostic Biomarker for Locally Advanced Prostate CancerBerna Tan1, Turgay Turan2, Burcu Yucel1, Sedef Altundağ Kara4, Seda Salman Yılmaz3, Asif Yildirim21Istanbul Medeniyet University, Medical School, Department Of Medical Biology, Istanbul2Istanbul Medeniyet University, Medical School, Department Of Urology, Istanbul 3Istanbul University, Cerrahpasa Medical School, Department Of Medical Genetics, Istanbul 4Istanbul Okan University, Medical School Department of Histology, Istanbul Objective: The aim of this study was to investigate the promoter methylation status of Ras-associated domain family 1A (RASSF1A), O-6-methylguanine-DNA methyltransferase (MGMT), Phosphatase with tensin homology (PTEN) and Suppressor of cytokine signaling 3 (SOCS3) tumor suppressor genes and evaluate the clinical utility of these genes as non-invasive, blood-based epigenetic biomarkers for Prostate Cancer (PCa) diagnosis. Lokal İlerlemiş Prostat Kanseri için Noninvaziv Diyagnostik Bir Biyobelirteç Olarak Sapmış SOCS3 Promotör MetilasyonuBerna Tan1, Turgay Turan2, Burcu Yucel1, Sedef Altundağ Kara4, Seda Salman Yılmaz3, Asif Yildirim21İstanbul Medeniyet Üniversitesi Tıp Fakültesi Tıbbi Biyoloji Ana Bilim Dalı, İstanbul2İstanbul Medeniyet Üniversitesi Tıp Fakültesi Üroloji Ana Bilim Dalı, İstanbul 3İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Tıbbi Genetik Ana Bilim Dalı, İstanbul 4Istanbul Okan Üniversitesi, Tıp Fakültesi, Histoloji Anabilim Dalı, İstanbul Amaç: Bu çalışmanın amacı tümör baskılayıcı genler Ras-associated domain family 1A (RASSF1A), O-6-methylguanine-DNA methyltransferase (MGMT), Phosphatase with tensin homology (PTEN) ve Suppressor of cytokine signaling 3 (SOCS3)’in promotör metilasyonlarını araştırmak ve bu genlerin Prostat Kanseri (PK) tanısı için noninvazif, kan temelli epigenetik biobelirteçler olarak klinik yararını değerlendirmekti. Berna Tan, Turgay Turan, Burcu Yucel, Sedef Altundağ Kara, Seda Salman Yılmaz, Asif Yildirim. Aberrant SOCS3 Promoter Methylation as a Noninvasive Diagnostic Biomarker for Locally Advanced Prostate Cancer. . 2020; 35(2): 99-105 Corresponding Author: Berna Tan, Türkiye |
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