. 2024; 34(1): 110-116 | DOI: 10.4274/anatoljmed.2023.88155 | ||||
Siblings with Severe Neonatal ARDS: Immune Deficiency Versus COVID-19Coşkun Armağan1, Tuğba Üçüncü Egeli1, Can Akyıldız1, Serdar Al2, Suna Asilsoy2, Funda Erdoğan1, Nuray Duman1, Hasan Özkan11Dokuz Eylül University Faculty of Medicine, Department of Neonatology, İzmir, Turkey2Dokuz Eylül University Faculty of Medicine, Department of Child Immunology and Allergic Diseases, İzmir, Turkey Neonatal acute respiratory distress syndrome (ARDS) is a relatively new diagnosis. Specific treatment, beyond managing the underlying disease, generally relies on lung protective ventilation strategies. Viral infections such as coronavirus-2 are associated with severe ARDS. Dysfunctions in innate immunity contribute to the loss of control over viral replication and inflammatory processes, inevitably leading to a more severe clinical presentation and poor outcomes. In this case report, we present the cases of two siblings diagnosed and managed as N-ARDS with severe combined immune deficiency related to adenosine deaminase deficiency. These cases highlight the challenges of managing neonatal ARDS and the severity of viral infections in patients with immune system disorders, underlining the impact of these conditions on clinical outcomes. Keywords: Neonatal ARDS, COVID-19, ADA deficiency, SCIDCoşkun Armağan, Tuğba Üçüncü Egeli, Can Akyıldız, Serdar Al, Suna Asilsoy, Funda Erdoğan, Nuray Duman, Hasan Özkan. Siblings with Severe Neonatal ARDS: Immune Deficiency Versus COVID-19. . 2024; 34(1): 110-116 Sorumlu Yazar: Coşkun Armağan, Türkiye |
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