Evaluation of Lesions with Increased Fluorine-18 Fluorodeoxyglucose Uptake in the Stomach and Colon Incidental Detected by Positron Emission Tomography/Computed TomographyDamla Çağla Patır1, Nurşin Agüloğlu2, Ömer Burçak Binicier3, Cengiz Ceylan11University of Health Sciences Turkey, İzmir Tepecik Training and Research Hospital, Clinic of Internal Medicine, İzmir, Turkey 2University of Health Sciences Turkey, Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, Clinic of Nuclear Medicine, İzmir, Turkey 3University of Health Sciences Turkey, İzmir Tepecik Training and Research Hospital, Clinic of Gastroenterology, İzmir, Turkey
Objective: One of the most common incidental increased uptake areas with fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) is the gastrointestinal tract. In this study, we retrospectively evaluated patients with gastric and colonic incidental increased 18F-FDG uptake on PET/CT. Methods: Patients who underwent 18F-FDG PET/CT imaging and had incidental increased gastric and colonic uptake between June 2017 and June 2020 were evaluated. Results: Of the 10,551 evaluated patients, 306 (2.9%) had colonic and 195 (1.8%) had gastric incidental 18F-FDG uptake on PET/CT. Within 120 days after imaging, 173 patients (56%) with increased colonic uptake (250 different uptake area) and 95 patients with increased gastric uptake (48.7%) who underwent endoscopic evaluation in our center were included in the study. Increased focal uptake pattern was seen in 86.4% of colonic uptake areas and 67.4% of gastric uptake areas. Malignant/premalignant diseases were identified in 80% of cases with colonic uptake, and in 21% of patients with gastric uptake areas. While maximum standardized uptake value (SUVmax) >5.9 in the colon differentiates inflammatory and malignant/premalignant diseases from benign diseases with 80% sensitivity and 97% specificity, SUVmax >5.0 in the stomach differentiates malignant/premalignant lesions from inflammatory benign diseases with 75% sensitivity and 72% specificity. Conclusion: Focal incidental increased 18F-FDG uptake especially in the colon is associated with malignant/premalignant events, however, focal gastric uptake is not effective in differentiating malignant/premalignant lesions from benign lesions. Studies are needed for effective SUVmax values distinguish benign and malignant gastric lesions. Keywords: Fluorine-18 fluorodeoxyglucose, positron emission tomography/computed tomography, incidental uptake, gastrointestinal tract
Damla Çağla Patır, Nurşin Agüloğlu, Ömer Burçak Binicier, Cengiz Ceylan. Evaluation of Lesions with Increased Fluorine-18 Fluorodeoxyglucose Uptake in the Stomach and Colon Incidental Detected by Positron Emission Tomography/Computed Tomography. . 2023; 33(3): 334-341
Sorumlu Yazar: Damla Çağla Patır, Türkiye |
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