. 2023; 33(1): 100-119 | DOI: 10.4274/terh.galenos.2023.60024 | ||||
Comparative Transcriptome Analysis Identifies Target Genes for Treatment of IDH Wild-type Lower-grade GliomasFadime Öztoprak1, Zerrin Işık2, Yavuz Oktay31Dokuz Eylül University, İzmir International Biomedicine and Genome Institute, İzmir, Turkey2Dokuz Eylül University Faculty of Engineering, Computer Engineering Department, İzmir, Turkey 3İzmir Biomedicine and Genome Center, İzmir, Turkey and Dokuz Eylül University Faculty of Medicine, Department of Medical Biology, İzmir, Turkey Objective: Isocitrate dehydrogenase 1/2 (IDH 1/2) mutations define a group of low-grade gliomas (LGGs) that display more favorable prognosis compared with LGGs without them. Although IDH wild-type (IDHwt) LGGs are classified as low-grade, they almost invariably progress to higher grades and rarely respond to aggressive treatment regimes. Here, we employed a comparative transcriptomic approach to identify key genes that could significantly contribute to the aggressive progression of IDHwt LGGs. Fadime Öztoprak, Zerrin Işık, Yavuz Oktay. Comparative Transcriptome Analysis Identifies Target Genes for Treatment of IDH Wild-type Lower-grade Gliomas. . 2023; 33(1): 100-119 Sorumlu Yazar: Yavuz Oktay, Türkiye |
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