. 2014; 20(5): 319-327 | DOI: 10.5505/tjtes.2014.39586  

The effects of Sildenafil in liver and kidney injury in a rat model of severe scald burn: A biochemical and histopathological study

Ali Kağan Gökakın1, Mustafa Atabey1, Koksal Deveci2, Enver Sancakdar2, Mehmet Tuzcu3, Cevdet Duger4, Omer Topcu1
1Cumhuriyet University School Of Medicine, Department Of General Surgery, Sivas/turkey
2Cumhuriyet University School Of Medicine, Department Of Biochemistry, Sivas/turkey
3Cumhuriyet University Faculties Of Veterinary, Department Of Pathology, Sivas/turkey
4Cumhuriyet University School Of Medicine, Department Of Anesthesiology, Sivas/turkey

Severe burn induces systemic inflammation and reactive oxygen species that leads to lipid peroxidation which may play a role in remote organs injury. Sildenafil is a selective and potent inhibitor of cyclic guanosine monophosphate specific phosphodiesterase-5. Sildenafil reduces oxidative stress and inflammation in distant organs. The aim of present study was to evaluate the effects of different dosages of sildenafil in remote organs injury. A total of 32 rats were randomly divided into four equal groups. The groups were designated as follows: Sham, Control, 10, and T20 mg/kg sildenafil treatment groups. Levels of malondialdehyde (MDA), vascular endothelial growth factor (VEGF), VEGF receptor (Flt-1), activities of glutathione peroxidase (Gpx), levels of total antioxidative capacity (TAC), and total oxidant status (TOS) were measured in both tissues and serum, a semi-quantitative scoring system was used for the evaluation of histopathological findings. Sildenafil increased levels of Gpx, and Flt-1, and decreased MDA and VEGF levels in tissues. Sildenafil also increased serum levels of TAC and Flt-1 and decreased TOS, OSI, and VEGF. Sildenafil decreased inflammation scores in remote organs in histopathological evaluation. Sildenafil has protective effects in severe burn-related remote organ injuries by decreasing oxidative stress and inflammation.

Keywords: scald burn, remote organ injury, Sildenafil


Ali Kağan Gökakın, Mustafa Atabey, Koksal Deveci, Enver Sancakdar, Mehmet Tuzcu, Cevdet Duger, Omer Topcu. The effects of Sildenafil in liver and kidney injury in a rat model of severe scald burn: A biochemical and histopathological study. . 2014; 20(5): 319-327

Sorumlu Yazar: Ali Kağan Gökakın, Türkiye


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