DENEYSEL SEPSİS MODELİNDE AKCİĞER PATOLOJİSİ VE ANTİBİYOTİKLERİN ETKİSİAydanur Mihmanlı1, Kemal Tahoğlu1, İlyas Şahin2, Birol Ağca2, Ali Kalyoncu1, Feyzullah Tuncer3, Damlanur Sakız41Süreyyapaşa Göğüs Hastalıkları Merkezi, İstanbul, Turkey 2Şişli Etfal Hastanesi 3. Genel Cerrahi Servisi, İstanbul, Turkey 3Şişli Etfal Hastanesi Enfeksiyon ve Mikrobiyoloji Kliniği, İstanbul, Turkey 4Şişli Etfal Hastanesi Patoloji Kliniği, İstanbul, Turkey
THE EFFECT OF ANTIBIOTIC THERAPY ON PROGNOSIS IN PATIENTS WITH SEVERE SEPSISAydanur Mihmanlı1, Kemal Tahoğlu1, İlyas Şahin2, Birol Ağca2, Ali Kalyoncu1, Feyzullah Tuncer3, Damlanur Sakız41Süreyyapaşa Göğüs Hastalıkları Merkezi, İstanbul, Turkey 2Şişli Etfal Hastanesi 3. Genel Cerrahi Servisi, İstanbul, Turkey 3Şişli Etfal Hastanesi Enfeksiyon ve Mikrobiyoloji Kliniği, İstanbul, Turkey 4Şişli Etfal Hastanesi Patoloji Kliniği, İstanbul, Turkey
AIMS: In this study. the effect of an extra-lung sepsis model on lung histopathology is evaluated. METHODOLOGY: In this study 20 Wistar-Albino rats were used. Following the ether anesthesia laparotomy was done. Caecum was ligated by a silk thread and was perforated by 18 gauge needle. It is squeezed untill feces emerged. Abdominal wall is closed. By this method peritoneal sepsis was perfor/ned. The rats are divided into two groups (n: 1 0). 0.5 ml of serum physiologic is applied to the control group, and imipenem is applied to the antibiotic group as 15 mg/kg/ tid. 48 hours later rats were sacrificied by extreme ether anesthesia.Relaparatomy was done and diaphragm was open. Multiple biopsies were made from the lung. Biopsy materials was cultured and examined histopathologically. RESULTS: In control group; rats died in 48 hours (%100),but antibiotic group were alive (%0). The results of lung biopsy cultures are; in all rats in control group, Escherichia coli (E. coli) and Bacteriodes fragilis (B.fragilis) were cultured (% 100). Whereas in antibiotic group there is no bacteria cultured (p< 0.001). Histopathologic results are: in control group there was wide spread edema and congestion and inflammatory reaction. In antibiotic group there was slight edema, congestion and inflammatory reaction. CONCLUSION: In septic condition sings of adult respiratory distress syndrome occurs. Large spectrum antibiotics can prevent nd bacterial translocation in lungs and could minimize the lung injury.
Aydanur Mihmanlı, Kemal Tahoğlu, İlyas Şahin, Birol Ağca, Ali Kalyoncu, Feyzullah Tuncer, Damlanur Sakız. THE EFFECT OF ANTIBIOTIC THERAPY ON PROGNOSIS IN PATIENTS WITH SEVERE SEPSIS. . 2002; 8(1): 3-5 |
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