Development and Optimization of Floating Multiparticulate Drug Delivery System of NorfloxacinRakesh Kumar Mishra, Tanaji Dilip Nandgude, Vaibhav Shivajirao SalveDepartment of Pharmaceutics, Dr. D.Y. Patil Institute of Pharmaceutical Sciences & Research, Pimpri, Pune, India.
INTRODUCTION: Norfloxacin is an synthetic broad-spectrum antibacterial drug having poor bioavailability and pH-dependent solubility. The purpose of present study was to develop gastroretentive floating multiparticulate drug delivery system of Norfloxacin. METHODS: The Norfloxacin core pellets were prepared using microcrystalline cellulose (MCC) and polyvinylpyrrilidone K30 (PVP K30) by extrusion and spheronization technique. A 3-level, 3-factor, 17 run experimental box-behnken design was adopted to optimize levels of variables in the pellets formulations. The selected independent variables were amount of MCC, PVP K30, spheronizing speed and dependent variables were aspect ratio and hardness of pellets. Sodium bicarbonate and Hydroxyl Propyl Methyl Cellulose K15M in the ratio of 1: 1, 1: 2 and 2: 1 (w/w) on a dry solid basis was incorporated into Norfloxacin pellets and was further coated with EudragitRL100 using fluidized bed processor to obtain weight gain of 5%, 10% and 15% w/w. RESULTS: Among the floating multiparticulate pellets batches, batch B-22 was found to be optimized based on the criteria of attaining minimum floating lag time (<10 minutes), and maximum value of drug released 82.11% in 8 hours. The percentage drug release for batch B-21 and B-23 was found to be 91.12% in 5 hours and 60.67% in 8 hours respectively. The drug release studies indicated that as the Eudragit RL 100 polymer coat increases the drug release gets decreased produces sustained release of Norfloxacin. The floating studies reveal that 70–90% of pellets remained floating for up to 8 hrs. DISCUSSION AND CONCLUSION: The significant outcome obtained with the study indicates that such an approach can be effectively employed for improvement of bioavailability of drugs having poor absorption in lower part of the gastrointestinal tract with enhanced therapeutic efficacy.
Keywords: Gastroretentive, Floating multiparticulate, Norfloxacin, Spheronization and Box-behnken design.
Rakesh Kumar Mishra, Tanaji Dilip Nandgude, Vaibhav Shivajirao Salve. Development and Optimization of Floating Multiparticulate Drug Delivery System of Norfloxacin. . 2019; 16(3): 326-334
Corresponding Author: Rakesh Kumar Mishra, India |
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