Synthesis and evaluation of vanillin derivatives as antimicrobial agents

The present work involves the synthesis of novel acetyl vanillin derivatives and evaluation for their anti-microbial potential against Escherichia coli. The titled compounds were prepared by reacting acetyl nitro vanillin with different substituted amines (Schiff base). The starting material acetyl nitro vanillin was synthesized by reacting acetyl vanillin with fuming nitric acid which in turn was prepared from 4-hydroxy-3-methoxybenzaldehyde (vanillin). The chemical structures of the synthesized compounds were confirmed on the basis of their spectral data (FT-IR, UV/Visible, 1H-NMR, Mass spectra). All the synthesized compounds were tested in vitro for antimicrobial activity and compound F & I showed significant activity as compared to the standard drug.