Development and Validation of In-Vitro Discriminatory Dissolution Testing Method for Fast Dispersible Tablets of BCS Class II drug

INTRODUCTION: Fast dispersible tablets (FDTs) get dispersed very fast due to which the discrimination of in-vitro drug release and their evaluation is difficult. Hence in the present study a new in-vitro discriminatory dissolution method was developed and validated for FDTs of domperidone of BCS class II.
METHODS: FDTs of domperidone were prepared by direct compression method. The dissolution studies were performed in an eight- station Electrolab TDT-082 dissolution testing apparatus, analyzed by UV spectrophotometer and evaluated in different dissolution mediums i.e. sodium lauryl sulphate (0.5%, 1.0% and 1.5%) with fresh distilled water, simulated intestinal fluid (SIF) pH 6.8, simulated gastric fluid (SGF) pH 1.2 without enzymes, phosphate buffer solution (PBS) (pH 6.8) and 0.1N hydrochloric acid (HCl) at different agitation speeds.
RESULTS: The developed method was validated in terms of specificity, accuracy, precision, linearity and robustness. Amongst the different mediums, 0.5% SLS with distilled water was found to be optimum with higher rate of discriminatory power. The percentage recovery was found to be 96 to 100.12 % and the % RSD value for precision (intraday and interday) was found to be less than 1%. Also a dissolution profile of prepared FDTs were compared in distilled water containing 0.5% SLS using similarity (f2) & dissimilarity (f1) factor calculation which showed dissimilarity in release profile and confirms the discriminatory nature of developed method.
DISCUSSION AND CONCLUSION: The discriminatory dissolution method for FDTs was developed and validated. All the obtained results were satisfactory, accurate and in range. The current method could be beneficial for formulation development and for assessment of quality of FDTs.