. 2019; 16(1): 0-0

Sub-chronic toxicity assessment of orally administered methanol (70%) seed extract of Abrus precatorius L. in Wistar albino rats

Shazia Tabasum1, Swati Khare2, Kirti Jain1
1Department of Botany, Govt. Science and Commerce College, Benazeer, Bhopal, Madhya Pradesh, India.
2Department of Botany, Govt. MLB Girls PG Autonomous College, Bhopal, Madhya Pradesh, India.

INTRODUCTION: Abrus precatorius L. is a famous medicinal plant of family Fabaceae and is widely used in traditional medicine for the treatment of various ailments. However, there is little toxicological data available regarding its safety following repeated exposure; therefore, the present study was designed to evaluate the 28 days sub-chronic toxicity of methanol (70%) crude extract of Abrus precatorius seeds in adult Wistar albino rats.
METHODS: Sub-chronic toxicity experiment was conducted by oral administration of graded doses (200 mg/kg and 400 mg/kg) of test extract daily for 28 days. Signs of toxicity, food and water consumption, body weight, gross pathology as well as relative organ weight were evaluated. The toxic effects were also assessed using hematological and biochemical data followed by histopathological examination of various internal organs. All data collected were expressed as mean ± standard deviation (SD). The One Way Analysis of Variance (ANOVA) followed by Bonferroni test was used for data interpretation and p ˂ 0.05 was considered as significant.
RESULTS: No deaths or evident toxic signs were found throughout the experimental period. There were no significant change in body weight, gross pathology, organ weight or food and water consumption between control and the treated groups. There were no treatment related differences in haematological and biochemical indices. Also, no gross abnormalities or histological alterations were observed.
DISCUSSION AND CONCLUSION: The methanol extract of Abrus precatorius seeds was found non-toxic in sub-chronic intake at the dosages tested. Thus, this study is expected to be beneficial for clinical and traditional applications for safe consumption and to utilize Abrus precatorius as a remedy at a recommended dosage.

Keywords: Abrus precatorius, sub-chronic toxicity, haematology, histopathology, biochemical indices


Shazia Tabasum, Swati Khare, Kirti Jain. Sub-chronic toxicity assessment of orally administered methanol (70%) seed extract of Abrus precatorius L. in Wistar albino rats. . 2019; 16(1): 0-0

Corresponding Author: Shazia Tabasum, India


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