. 2019; 16(4): 425-431

Effect of surfactant on azithromycin dihydrate loaded stearic acid solid lipid nanoparticles

Sayani Bhattacharyya, Priyanka Reddy
Department of Pharmaceutics, Krupanidhi college of Pharmacy, Bangalore, India

INTRODUCTION: Azithromycin dihydrate is a macrolide antibiotic used for the treatment of several types of bacterial infections. The drug shows low oral bioavailability due to its low solubility. In this present work solid lipid nanoparticles of azithromycin dihydrate has been formulated, keeping in view to enhance the solubility and rate of dissolution of the drug.
METHODS: The azithromycin dihydrate loaded stearic acid nanoparticles were formulated by high shear homogenization method using three different surfactants namely Tween 20, Poloxamer 188 and Poloxamer 407 at a varied lipid surfactant ratio while keeping the quantities of active ingredient constant. Twelve such formulations were prepared. The nanoparticles obtained were evaluated for drug content, % drug loading, % entrapment efficiency, particle size analysis, zeta potential, surface morphology, Fourier Transmission infrared spectroscopy, invitro drug release,stability study.
RESULTS: All the formulations showed good entrapment efficiency and high percentage of invitro release with a particle size suitable for lymphatic absorption. The nanoparticles formulated with poloxamer 188 showed better characteristics compared to other surfactants.
DISCUSSION AND CONCLUSION: This study indicates that stearic acid nanoparticles of azithromycin dihydrate prepared by high shear homogenization method can be successively used for improvement of dissolution and thereby oral bioavailability of the drug.

Keywords: Azithromycin dihydrate, Solid lipid nanoparticles (SLN), Zeta potential, particle size, entrapment efficiency, drug release.


Sayani Bhattacharyya, Priyanka Reddy. Effect of surfactant on azithromycin dihydrate loaded stearic acid solid lipid nanoparticles. . 2019; 16(4): 425-431

Corresponding Author: Sayani Bhattacharyya, India


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