. 2019; 16(2): 0-0

Study of the tableting properties of MCR, a newly co-processed cellulose based direct compression excipient

Salah Aly
Department of Pharmaceutics, AlJouf University, Sakaka, KSA.

INTRODUCTION: Co-processing technique has been utilized to develop excipients of improved or/and desired functionalities. Silicified MCC (Prosolve), cellactose and Avicel CE-15 are commercially available co-processed excipients which have improved flow and consolidation properties. One of the major limitations challenging co-processing technique is the fixed ratio of the excipients in a co-processed mixture which may not be an optimum choice for the active ingredient (s) and the dose per a formulation under development.
Trials were made to co-process excipients to manufacture direct compression MZ tablets.
The objective of this work was to co-process and evaluate the tableting properties of (MCR), a new cellulose-based tableted excipient produced from the slugs from the granules of CMCC/CRC. Metronidazole a model of non-freely flowing incompressible API was employed to evaluate MCR for the production of direct compression MZ tablets.


METHODS: Methods: Processing and evaluation of CMCC and CRC: CMCC and CRC were processed and evaluated for their physico-chemical properties.
Processing of MCR: MCR was produced by sifting the slugs of 4: 1 CMCC/CRC granules made with alcohol.. MCR was characterized and evaluated and used to compress MZ tablets.
Evaluation of MZ tablets: The produced MZ tablets were evaluated for their physico-chemical properties.

RESULTS: CMCC and CRC were successfully processed and the prepared MCR was successfully co-processed. The compressed MZ tablets were evaluated. Their mechanical properties and disintegration and dissolution behaviors were satisfactory. MCR was sensitive to magnesium stearate (MS) and moisture.
DISCUSSION AND CONCLUSION: MCR proved to be a direct compression excipient of adequate
tableting properties. Tablets of accepted mechanical properties and fast disintegrating and dissolving rates were produced. MCR is recommended to be applied as a direct compression excipient. It is unfortunately sensitive to MS and moisture which may limit its use

Keywords: Micro-crystalline cellulose, Regenerated cellulose, MCR co-processing, MCR tableting properties of MCR.


Salah Aly. Study of the tableting properties of MCR, a newly co-processed cellulose based direct compression excipient. . 2019; 16(2): 0-0

Corresponding Author: Salah Aly, Saudi Arabia


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