Development of the composition and manufacturing technology of the new combined drug LavaflamTanya Ivko1, Milena Aslanian3, Larisa Bobrytska3, Natalia Popova3, Olena Nazarova2, Natalia Bereznyakova3, Tamara Germanyuk11National Pirogov Memorial Medical University, Vinnytsya, Ukraine 2State Enterprise «State Scientific Center for Drugs and Medical Products», Kharkov, Ukraine 3National University of Pharmacy, Kharkov, Ukraine
INTRODUCTION: Treatment of diseases of the biliary system is one of the urgent problems of modern medicine METHODS: For a complex treatment of diseases of the biliary system it was proposed the original pharmaceutical drug in the form of combined tablets «Lavaflam», which include the composition of herbal components of flamin (0.05 g) and lavender oil (0.02 g). Flamin is phytomedicine from the immortelle flowers (Helichrysum arenarium (L.) Moench, Asteraceae), which contains a complex of active substances from the group of flavonoids (salipurposide, isosalipurposide, kaempferol, luteolin, etc.). It is applied as a choleretic and anti-inflammatory agent in the case of cholecystitis, cholangitis and biliary dyskinesia. Tablets were prepared by pressing for separate granulation technology. RESULTS: Lavender oil granulate is prepared by solid phase method, as an excipient substance was used β-cyclodextrin. Flamin granulate was prepared by mixing with spherical shape filler mannitol PARTECK M 200. On the basis of studies designed composition tablet excipients «Lavaflam»: β-cyclodextrin (0.27 g), mannitol PARTECK M 200 (0.20 g), croscarmellose sodium (0.03 g), potato starch (0,022 g), PEG 6000 (0.002 g), magnesium stearate (0.006 g). Assay of the main components of lavender oil with the reference into linalol and linalyl acetate was performed by gas chromatography. Assay of total flavonoids of flamin was performed by spectrophotometric method with reference into isosalipurposide. DISCUSSION AND CONCLUSION: New phytomedicine tablets «Lavaflam» meets European Pharmacopoeia requirements on the following parameters: appearance, geometrical sizes, average weight, disintegration, friability, resistance of tablets to crushing, quantification.
Keywords: lavender oil, flamin, tablets Lavaflam
Tanya Ivko, Milena Aslanian, Larisa Bobrytska, Natalia Popova, Olena Nazarova, Natalia Bereznyakova, Tamara Germanyuk. Development of the composition and manufacturing technology of the new combined drug Lavaflam. . 2018; 15(3): 0-0
Corresponding Author: Tanya Ivko, Ukraine |
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