. 2019; 16(1): 0-0

Histone Deacetylase Inhibitors: A Prospective In Drug Discovery

Rakesh Yadav, Pooja Mishra, Divya Yadav
Department Of Pharmacy, Banasthali University, Banasthali, Rajasthan, India

Treatment of cancer is a major provocation in the entire society and follows a line of an investigation in the field of drug discovery. Therefore, there is a crucial requirement of discovering an ingenious medicinally active agent with proficiency of amending idle drug targets. Increasing pragmatic evidences implies that the histone deacetylases (HDAC) are trapped in cancer progression which increases the deacetylation and triggers malignancy changes. They provide a ground-breaking scaffolds and an attainable key for investigating chemical entity pertinent to HDAC biology as a therapeutic target in drug discovery context. Due to the gene expression, an impending requirement to prudently transfer cyto-toxicity to cancerous cells, HDAC inhibitor may be developed as an anti-cancerous agent. The present review has been focused on the basics of HDAC enzyme, their inhibitors and therapeutic outcomes.

Keywords: Histone deacetylase inhibitors, Apoptosis, Multi-therapeutic approach, Cancer


Rakesh Yadav, Pooja Mishra, Divya Yadav. Histone Deacetylase Inhibitors: A Prospective In Drug Discovery. . 2019; 16(1): 0-0

Corresponding Author: Rakesh Yadav, India


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