Synthesis and Antioxidant Properties of New Oxazole-5(4H)-one Derivatives
Canan Kuş1, Ezgi Uğurlu1, Elçin D Özdamar2, Benay Can-Eke21Ankara University, Faculty Of Pharmacy, Department Of Pharmaceutical Chemistry, Tandoğan, Ankara, Turkey2Ankara University, Faculty Of Pharmacy, Department Of Pharmaceutical Toxicology, 06100-tandoğan, Ankara, Turkey
A series of 4-(substituted benzylidene)-oxazole-5(4H)-one derivatives (E1-E10) were synthesized and tested for their antioxidant activities. The structures of the new derivatives were elucidated by spectral techniques. The most active analogue on the microsomal ethoxyresorufin O-deethylase (EROD) activity was E3 (89%), and was similarly better than that of the specific inhibitor caffeine (85%) at 10-3 M concentration.
Keywords: Oxazolidinones, Synthesis, Antioxidant activity, Lipid peroxidation, EROD activityYeni Oksazol-5(4H)-on Türevlerinin Sentez ve Antioksidan Özellikleri
Canan Kuş1, Ezgi Uğurlu1, Elçin D Özdamar2, Benay Can-Eke21Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Ana Bilim Dalı, Ankara2Ankara Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Ana Bilim Dalı, Ankara
Bir seri 4-(sübstitüe benzyliden)-oksazol-5(4H)-on türevi (E1-E10) sentezlendi ve antioksidan etkileri incelendi. Yeni türevlerin yapıları spektral yöntemler ile tanımlandı. Mikrozomal etoksiresorfin O-deetilaz (EROD) enzimi üzerinde 10-3 M konsantrasyonda, en etkili türev E3 (%89), spesifik inhibitör kafeinden (%85) bir miktar daha etkilidir.
Anahtar Kelimeler: Oksazolidinonlar, Sentez, Antioksidan aktivite, Lipid peroksidasyon, EROD aktiviteCorresponding Author: Canan Kuş, Türkiye
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