The Structural, Crystallinity and Thermal Properties of pH responsive Interpenetrating Gelatin/Sodium Alginate Based Polymeric Composites for the Controlled Delivery of Cetirizine HCl

Objectives: The present work was aimed to design and synthesize pH-sensitive crosslinked Ge/SA hydrogels using different ratios of each polymer and to investigate the effect of each polymer on dynamic, equilibrium swelling and in vitro release pattern of cetirizine hydrochloride which was selected as a model drug.
Materials and Methods: These gelatin and sodium alginate hydrogels were prepared at room temperature by free radical polymerization technique using glutaraldehyde as a crosslinker. These polymeric composites were used as model systems to envisage various important characterizations. In vitro release pattern of drug was investigated in three different mediums (phosphate buffer solution of pH 1.2, 5.5, 7.5 whose ionic strength was kept constant. Various structure property relationships that affect its release behavior were determined like swelling analysis, porosity, sol-gel analysis, average molecular weight between crosslinks (Mc), solvent interaction parameter (χ), volume fraction of polymer (V2,s) and diffusion coefficient. The structural, crystallinity and thermal stability was confirmed by FTIR, XRD and DSC analysis.
Results: These hydrogels showed maximum swelling at pH 1.2. Zero order, First order, Higuchi and Peppas models were applied to demonstrate the release pattern of drug. The release of drug occurred through non-fickian diffusion or anomalous mechanism. Porosity was found increased with an increase in concentration of both the polymers and when concentration of crosslinker was increased porosity decreased. Gel fraction increased with an increase in concentration of SA, Ge and glutaraldehyde.
Conclusion: The prepared pH sensitive hydrogels can be used as a potential carrier for the sustained delivery of cetirizine hydrochloride.