Enhancement of Dissolution of Fenofibrate using complexation with Hydroxy propyl β – Cyclodextrin

INTRODUCTION: The aim of the present study was to enhance the dissolution rate of fenofibrate using its complexation with Hydroxy prypyl β – Cyclodextrin (HPβCD).
METHODS: The phase solubility behavior of fenofibrate was studied in presence of various concentrations of (HPβCD) in aq. Solution at 37°c.
The complexes of fenofibrate were prepared with HPβ – Cyclodextrin at 1: 1 ratio by kneading and co- precipitation method. Fenofibrate – HPβCD complexes were evaluated by dissolution studies, Fourier transform infrared (FTIR) spectroscopy and Differential scanning calorimetry (DSC) studies.
RESULTS: The solubility of fenofibrate increased with increase in amount of HPβCD in aq. Solution. Gibbs free energy (ΔG0)tr values were all negative.
The complexation of fenofibrate with HPβ – Cyclodextrin exhibited enhanced dissolution rate of fenofibrate. The mean dissolution time of fenofibrate decreases significantly in complexation. The Fourier transform infrared (FTIR) spectroscopy studies showed formation of intermolecular hydrogen bonding between fenofibrate and HPβ – Cyclodextrin. The Differential scanning calorimetric studies indicated the loss in crystalline state of fenofibrate in complexes of fenofibrate with HPβ – Cyclodextrin.
DISCUSSION AND CONCLUSION: The studies indicated the loss in crystalline state of fenofibrate in complexes of fenofibrate with HPβ – Cyclodextrin. From Study, it can be concluded that Fenofibrate - HPβ-CD complexation results in an increase in solubility and dissolution rate of drug, suggesting a possible enhancement of its oral bioavailability