Considering the effect of Rosa Damascena essential oil on oxidative stress and COX-2 gene expression in liver of septic rats

INTRODUCTION: Sepsis is a clinical illness with the high rate of mortality in all over the world. Oxidative stress considered as the main phenomenon which occurs in sepsis. Rosa Damascena supposed as an ancient herbal planet with high pharmacological activities.
METHODS: CLP operation as a standard model was done to induce sepsis in rats. Male adult rats were randomly divided into 5 groups. Rosa Damascena E.Os (50 and 100 mg/kg.bw), was gavaged orally for 14 days, and in the day 15th, CLP was performed. After 24 hours, the blood samples and liver tissues were removed in order to measure oxidative stress (MPO, MDA, GSH, GST, FRAP) and biochemical parameters (ALP, AST, ALP, bilirubin) together with plasma PGE2 and COX-2 expression.
RESULTS: We deduced that E.Os had capable to modulate all of the oxidative stress, antioxidant and anti-inflammatory parameters induced by CLP as characterized by the elevations in MPO and MDA levels as well as increases in AST and ALT concentrations concomitant with PGE2 and COX-2 increments. The antioxidant defense system such as GSH and FRAP was also increased in E.O treated groups.
DISCUSSION AND CONCLUSION: Our results showed that E.Os has antioxidative and hepatoprotective activities through reducing the oxidative injury in sepsis caused by CLP.