Nootropic Activity of Vitis Vinifera Juice in Normal and Memory-Impaired Mice Using Spatial Learning and Recognition Memory Paradigms
Muhammad Aslam, Nuzhat SULTANADepartment Of Pharmacology, Faculty Of Pharmacy, University Of Karachi-75270, PakistanVitisvinifera Linn. (Grape) contains a variety of bioactive components including polyphenols. Flavonoids are the major phenolic compounds (65–76%) in grapes. Grapephenolicspossessseveralhealthpromotingpropertiesdue to their antioxidant potential. It is thought that antioxidants have memory-enhancing potential. Therefore, in thisstudy, weevaluatedthenootropicactivity of theVitisvinifera fruit juice in normal and memory-impaired mice using the Morris water maze model and object recognition test. In the Morris water maze model, there was a significant decrease in escape latency (EL) and a significant increase in time spent in the target quadrant (TSTQ) as compared with normal control and memory-impaired mice (P < 0.001). In the object recognition test, there was a significant increase in the discrimination index (P < 0.001). Thesefindingssuggestedthepossibleuse of Vitisviniferajuicetowards a widerange of cognitivedisabilityandproposedthenootropicactivity of theVitisviniferajuice.
Keywords: Vitisvinifera, Memory-enhancing, Dementia, Nootropic, Morris water maze, Object recognition testNootropic Activity of Vitis Vinifera Juice in Normal and Memory-Impaired Mice Using Spatial Learning and Recognition Memory Paradigms
Muhammad Aslam, Nuzhat SULTANADepartment Of Pharmacology, Faculty Of Pharmacy, University Of Karachi-75270, PakistanVitisvinifera Linn. (Grape) contains a variety of bioactive components including polyphenols. Flavonoids are the major phenolic compounds (65–76%) in grapes. Grapephenolicspossessseveralhealthpromotingpropertiesdue to their antioxidant potential. It is thought that antioxidants have memory-enhancing potential. Therefore, in thisstudy, weevaluatedthenootropicactivity of theVitisvinifera fruit juice in normal and memory-impaired mice using the Morris water maze model and object recognition test. In the Morris water maze model, there was a significant decrease in escape latency (EL) and a significant increase in time spent in the target quadrant (TSTQ) as compared with normal control and memory-impaired mice (P < 0.001). In the object recognition test, there was a significant increase in the discrimination index (P < 0.001). Thesefindingssuggestedthepossibleuse of Vitisviniferajuicetowards a widerange of cognitivedisabilityandproposedthenootropicactivity of theVitisviniferajuice.
Anahtar Kelimeler: Vitisvinifera, Memory-enhancing, Dementia, Nootropic, Morris water maze, Object recognition testCorresponding Author: Muhammad Aslam, Pakistan
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