Local use of Apisan gel, a new oral care product in the treatment of experimental periodontitis against the background of hyperacid gastritis and intoxication with tobacco smoke

INTRODUCTION: Changes in the tissues of the oral cavity with manifestations of inflammation are often associated with diseases of the gastrointestinal tract (GIT), which is due to the morphofunctional unity of the digestive apparatus. The presence of harmful habits, especially smoking, in patients with concomitant diseases of GIT further enhances the severity of the inflammatory symptoms in the oral cavity. Dental deposit of smokers is a major provocative factor in the development of gum disease, caries.
METHODS: During the study, there were used general principles of animal experiments approved at the National Congress on Bioethics (Kyiv, Ukraine, 2001) and in accordance with the provisions of the European Convention for the Protection of Vertebrate Animals used for experimental and other scientific purposes (Strasbourg, France, 1985). The statistical processing of the data was carried out using the program "Statistica 6.0" using the Student t-criterion. The changes were considered to be significant at p <0.05.
RESULTS: In the experimental periodontitis against the background of hyperacidic gastritis under the conditions of tobacco smoking, there were significant changes in the periodontal tissues characteristic of the inflammatory process: the activity of POL increased and activity of the antioxidant system decreased, inflammatory markers increased when non-specific protection was reduced. Local therapy in the rats using the new "Apisan" gel resulted in correction of certain metabolic disorders, faster elimination of the harmful effects of the damaging factors and restoration of the condition of periodontal tissues than with the use of the comparator - the Asepta gel.
DISCUSSION AND CONCLUSION: The therapeutic effectiveness of the new Apisan gel is due to the normalizing effect on the processes of POL, inflammation and activation of the oral cavity protective systems during inflammatory periodontal disease occurring against the background of concomitant stomach pathologies - hyperacidic gastritis.