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Comparative Clinical Study of Effectiveness of “MEKRITEN” in Patients with Chronic Suppurative OtitisAbror Mukhitdinov, Nemat Olimov, Shirinkhan OlimovaDepartment Of Pharmaceutical Chemistry, Tashkent Pharmaceutical Institute, Tashkent, UzbekistanBackground. Chronic suppurative otitis media (CSOM) is a serious disease with the presence of bacterial infection in the middle ear. The study of wound healing efficacy and tolerability of the drug "Garlic Extract liquid" is dedicated to identify the possibility of issuing recommendations to the drug for clinical use in the RUz. The main group of patients, who received the study-drug, consisted of 30 patients; in the group of patients who receiving the comparison drug, there were 20 patients. Patients of the main group (30 persons) were appointed "Garlic Extract liquid" which was developed by the Tashkent Pharmaceutical Institute, and it was used to 2 drops 2 times a day for 10 days in the external auditory canal. Patients in the comparison group (20 people), took other drugs (0.25% solution of Levomycetin) in a similar way. Patients were inspected and observed carefully for determining severity of the complaints such as pain, secretion (in points); and checked clinical analyses: GBA, urine etc. Additionally, observers studied biochemical (ALT, AST, bilirubin), instrumental (ultrasound of the liver) and special (fibrous tissue biopsy and echinococcal capsules) analyses. The average rating of the tolerability and effectiveness in the points for "MEKRITEN" made portability of 4.97 points, and the effectiveness was 4.77 points, for 0.25% Levomycetin solution they were 4.8 and 3.35 points, respectively. While receiving "MEKRITEN", no side effects and allergic reactions were observed. The research for a particular patient can be stopped if patient has adverse reactions requiring discontinuation of the drug, or the ineffectiveness of the drug in this patient, or if he missed taking the drug, or refusal of the patient from further participation in the study. Local therapy with the drug "MEKRITEN" (Garlic Extract liquid) in patients with chronic suppurative otitis media is more effective than local application of 0.25% Levomycetin solution. Keywords: MEKRITEN, Levomycetin, Chronic suppurative otitis media, Garlic Extract liquidKronik süpüratif otitli hastalardaAbror Mukhitdinov, Nemat Olimov, Shirinkhan OlimovaFarmasötik Kimya Bölümü, Taşkent Eczacılık Enstitüsü, Taşkent, ÖzbekistanGiriş. Kronik süpüratif otitis media (KSOM), orta kulakta bakteri enfeksiyonu bulunan ciddi bir hastalıktır. Dünya çapında, gelişmiş ve gelişmekte olan ülkelerde yaşayan nüfusun 1% - % 46' sında kronik süpüratif otitis media muzdarip, yaklaşık 65-330 milyon insan, bunların % 60'ında önemli işitme kaybı var. Özbekistan Cumhuriyeti'nde klinik kullanım için uyuşturucuya tavsiyede bulunma olasılığını belirlemek için "Sarımsak Özü sıvısı" ilacının yara iyileştirme etkinliğinin ve tolere edilebilirliğinin incelenmesi. Abror Mukhitdinov, Nemat Olimov, Shirinkhan Olimova. Comparative Clinical Study of Effectiveness of “MEKRITEN” in Patients with Chronic Suppurative Otitis. . 2018; 15(2): 0-0 Corresponding Author: Abror Mukhitdinov, Uzbekistan |
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