Bio fabrication of Copper Nanoparticles: A Next Generation Antibacterial Agent against Wound Associated Pathogens

INTRODUCTION: Background/Aim The impaired wound healing is a major complication. Few factors like blood glucose level, poor circulation, Immune System Deficiency, and Infection are the root cause of impaired wound healing. Thus the present study aims at bio-synthesizing copper nanoparticles with potential antibacterial activity against wound associated pathogens.
METHODS: Materials and Methods: The copper nanoparticles were fabricated utilizing sol gel method with the mixing of Syzigium cumini leaf extract in metal salt solution. The particles were then later chararacterized by utilizing UV spectroscopy, SEM, TEM, FTIR, XRD etc. and evaluation for their antibacterial activity and its MIC against four wound associated pathogens.
RESULTS: Results: The results obtained from TEM, SEM and XRD characterization showed the particle size i.e. below 100nm and of spherical shape. The FTIR analysis showed the possibility of various bio molecules which have role in capping and stabilization of the copper nanoparticles. The particles synthesized showed antibacterial activity against four wound associated pathogens i.e. P. mirabilis, S. saprophyticus, S. pyogenes, and P. aeroginosa.
DISCUSSION AND CONCLUSION: Conclusion: The Biosynthesized copper nanoparticles showed potent antimicrobial activity, thus the antibacterial activity of the synthesized copper nanoparticles could be utilized in several biomedical applications additionally they can be exploited as a better therapeutic agent for treating infection seen in impaired diabetic wounds etc. Withal, the particles synthesized by biological route are eco-amicable, less toxic, feasible and cost efficacious.