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Effects of glycyrrhetic acid on human chronic myelogenous leukemia cellsHalilibrahim CiftciDepartment of Bioorganic Medicinal Chemistry, Kumamoto University, Kumamoto, JapanINTRODUCTION: Chronic myelogenous leukemia (CML) is a type of blood cancer which is initially treated with imatinib (first Abl kinase inhibitor). However, some patients with CML are able to develop imatinib resistance. Several new generation drugs have been developed, but do not overcome this problem. Glycyrrhetic Acid (GA) is a plant-derived pentacyclic triterpenoid that exhibits multiple pharmacological properties for the treatment of cancers. The current study aims to investigate the effects of GA on K562 cell line (Bcr-Abl positive leukemia). Halilibrahim Ciftci. Effects of glycyrrhetic acid on human chronic myelogenous leukemia cells. . 2020; 17(1): 49-55 Corresponding Author: Halilibrahim Ciftci, Japan |
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