. Ahead of Print: TJPS-46095 | |||
Electrochemical Properties of Fused Pyrimidine-Triazole Heterocyclic Molecules as Novel Drug CandidatesFatma Kurul1, Hüseyin Istanbullu2, Hüseyin Ošuzhan Kaya3, Arif E. Cetin4, Seda Nur Topkaya31Izmir International Biomedicine and Genome Institute, Dokuz Eylul University2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Izmir Katip Celebi University 3Department of Analytical Chemistry, Faculty of Pharmacy, Izmir Katip Celebi University 4Izmir Biomedicine and Genome Center, Balcova, Izmir 35340, Turkey INTRODUCTION: Triazolopyrimidinones are a type of compound used in medicinal chemistry. In this study, three novel triazolopyrimidinone derivatives were synthesized as drug candidates which are named ((5-(Chloromethyl)-2-(4-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one) (S1-TP), 2-(4-Methoxyphenyl)-5-(piperidinomethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one (S2-TP), and 2-(4-Methoxyphenyl)-5-(morpholinomethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one (S3-TP). Their electrochemical properties were investigated for the first time with voltammetric techniques on carbon graphite electrodes. Moreover, stability tests for each drug candidate were performed on different days. After revealing the electrochemical properties of drug candidates, their effect on double-stranded (ds) DNA was examined by measuring the oxidation currents of the guanine of dsDNA before and after the interaction. Corresponding Author: Seda Nur Topkaya, Türkiye |
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