. 2017; 14(1): 0-0

Cutaneous Wound Healing after Topical Application of Pistacia atlantica Gel Formulation in Rats

Seyed Ahmadreza Hamýdý1, Aboutorab Tabatabaeý Naeýný2, Ahmad Oryan3, Mohammad Reza Tabandeh4, Nader Tanýdeh5, Saeed Nazýfý1
1DVM, DVSc in veterinary surgery, School of Veterinary Medicine, Shiraz University, Shiraz, Iran, student in dentistry, KIMS Collage branch of Rajiv Gandhi University, bangalouru, India
2Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
3Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
4Department of Biochemistry, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
5Department of Stem Cell and Transgenic Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

This study has been undertaken to investigate the antioxidant activity of the gels formulation, from Pistacia atlantica oil extraction on enzymatic antioxidants in experimental wound created in rat.Under taken anesthesia; a square-shaped skin defect (2×2cm) was created aseptically by surgical incision. Then animals were randomly allocated in four groups (I- untreated controls, II- topically treated base gel, III- topically treated 5% gel, IV- topically treated 10% gel). These results suggest that topical application of Pistacia atlantica oil gels improved reepithelialization with continuous stratum basalis and a mature granulation tissue and adnexa (hair follicles and sweat gland) compared with control and base gel groups. Treatment with 10% oil gel significantly enhanced the tensile strength, ultimate stress, yield strength and stiffness of this group compared with the control and base gel group at 21 days post injury. The collagen fibers showed a more organized pattern and the tissue alignment was greater as compared to the control and base gel treated groups at the same stage. The results suggest that topical application of Pistacia atlantica oil gel improved the morphological, biochemical and biomechanical properties of experimentally-induced wound defects in rats.

Keywords: Pistacia atlantica, wound healing, histopathology, biomechanic, skin


Seyed Ahmadreza Hamýdý1, Aboutorab Tabatabaeý Naeýný2, Ahmad Oryan3, Mohammad Reza Tabandeh4, Nader Tanýdeh5, Saeed Nazýfý1
1DVM, DVSc in veterinary surgery, School of Veterinary Medicine, Shiraz University, Shiraz, Iran, student in dentistry, KIMS Collage branch of Rajiv Gandhi University, bangalouru, India
2Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
3Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
4Department of Biochemistry, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
5Department of Stem Cell and Transgenic Research Center, Shiraz University of Medical Sciences, Shiraz, Iran



Seyed Ahmadreza Hamýdý, Aboutorab Tabatabaeý Naeýný, Ahmad Oryan, Mohammad Reza Tabandeh, Nader Tanýdeh, Saeed Nazýfý. Cutaneous Wound Healing after Topical Application of Pistacia atlantica Gel Formulation in Rats. . 2017; 14(1): 0-0

Corresponding Author: Saeed Nazýfý, Iran


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