Preparation And Evaluatýon Of Chitosan Succinate Pellets Using Extrusion-Spheronization Technology: Processing And In Vitro Characterization
Ds Karuna1, Udhumansha Ubaidulla1, Grace Rathnam1, Ganesh Mani2, Hyun Tae Jang2, Ganesh Mani31Department of Pharmaceutics, C.L. Baid Metha College of Pharmacy, Chennai, India2Department of Chemical Engineering, Hanseo University, Seosan-si 356 706, South Korea
3Department of Pharmaceutical Chemistry, Hill Side College of Pharamcy, Kanakapura Main Road,Bangalore-560062,India
The study is aimed to investigate a novel approach for the preparation of multiparticulate drug delivery system using chitosan succinate a chitosan derivatives polymer. Herein the chitosan succinate multiparticulate pellets entrapped diclofenac sodium was prepared by extrusion and spheronization technique. FTIR results revealed that there were no interactions between the drug and polymer. The prepared pellets were with good spherical geometry and 1.02±0.40 mm as their mean diameter. Chitosan succinate showed pH dependent release profiles for the entrapped diclofenac sodium. Maximum drug release was observed at pH 7.4, whereas no drug release was observed at pH 1.2. The optimized formulation followed Higuchi kinetics while drug release mechanism was found to be anomalous type i.e controlled by diffusion through swollen matrix. These results may be concluded that a new pharmaceutical carrier which can capable of sustained release in oral drug delivery system.
Keywords: Chitosan succinate pellets, pH sensitive drug release, Chitosan, sustained release, extrusion-spheronization.Preparation And Evaluatýon Of Chitosan Succinate Pellets Using Extrusion-Spheronization Technology: Processing And In Vitro Characterization
Ds Karuna1, Udhumansha Ubaidulla1, Grace Rathnam1, Ganesh Mani2, Hyun Tae Jang2, Ganesh Mani31Department of Pharmaceutics, C.L. Baid Metha College of Pharmacy, Chennai, India2Department of Chemical Engineering, Hanseo University, Seosan-si 356 706, South Korea
3Department of Pharmaceutical Chemistry, Hill Side College of Pharamcy, Kanakapura Main Road,Bangalore-560062,India
The study is aimed to investigate a novel approach for the preparation of multiparticulate drug delivery system using chitosan succinate a chitosan derivatives polymer. Herein the chitosan succinate multiparticulate pellets entrapped diclofenac sodium was prepared by extrusion and spheronization technique. FTIR results revealed that there were no interactions between the drug and polymer. The prepared pellets were with good spherical geometry and 1.02±0.40 mm as their mean diameter. Chitosan succinate showed pH dependent release profiles for the entrapped diclofenac sodium. Maximum drug release was observed at pH 7.4, whereas no drug release was observed at pH 1.2. The optimized formulation followed Higuchi kinetics while drug release mechanism was found to be anomalous type i.e controlled by diffusion through swollen matrix. These results may be concluded that a new pharmaceutical carrier which can capable of sustained release in oral drug delivery system.
Anahtar Kelimeler: Chitosan succinate pellets, pH sensitive drug release, Chitosan, sustained release, extrusion-spheronization.Corresponding Author: Udhumansha Ubaidulla, India
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