. 2019; 16(1): 0-0

Antiplasmodial activity of the n-hexane extract from Pleurotus ostreatus (Jacq. Ex. Fr) P. Kumm.

Ozadheoghene Eriarie Afieroho1, Xavier Siwe Noundou2, Chiazor P Onyia1, Osamuyi H Festus1, Elizabeth C Chukwu1, Olutayo M Adedokun3, Michelle Isaacs4, Heinrich C Hoppe4, Rui WM Krause2, Kio A Abo1
1Department of Pharmacognosy and Phytotherapy, University of Port Harcourt, Nigeria
2Department of Chemistry, Rhodes University, Grahamstown, 6140, South Africa
3Department of Crop & Soil Sciences, University of Port Harcourt, Nigeria.
4Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, 6140, South Africa

INTRODUCTION: Several mushrooms species have been reported to be nematophagous and anti-protozoan.This study reported the antiplasmodial and cytotoxic properties of the n-hexane extract from the edible mushroom Pleurotus ostreatus and the isolation of a sterol from the extract
METHODS: Anti-plasmodial and cytotoxicity assays were done in vitro using the plasmodium lactate dehydrogenase (pLDH) assay and human HeLa cervica cell lines respectively. The structure of the isolated compound from the n-hexane extract was elucidated using spectroscopic techniques.
RESULTS: The n-hexane extract (yield: 0.93 % w/w) showed a dose dependent anti-plasmodial activity with the trend in parasite inhibition of: chloroquine (IC50 = 0.016μg/ml) > n-hexane extract (IC50 = 25.18μg/ml). It also showed mild cytotoxicity (IC50 >100μg/ml; selectivity index >4) compared to the reference drug emetine (IC50 = 0.013 µg/ml). The known sterol: ergostan-5,7,22-trien-3-ol was isolated and characterized from the extract
DISCUSSION AND CONCLUSION: This study reporting for the first time the anti-plasmodial activity of P. ostreatus revealed its nutraceutical potential in the management of malaria.

Keywords: Pleurotus ostreatus, nutraceuticals, malaria, cytotoxicity, ergosterol


Ozadheoghene Eriarie Afieroho, Xavier Siwe Noundou, Chiazor P Onyia, Osamuyi H Festus, Elizabeth C Chukwu, Olutayo M Adedokun, Michelle Isaacs, Heinrich C Hoppe, Rui WM Krause, Kio A Abo. Antiplasmodial activity of the n-hexane extract from Pleurotus ostreatus (Jacq. Ex. Fr) P. Kumm.. . 2019; 16(1): 0-0

Corresponding Author: Ozadheoghene Eriarie Afieroho, Nigeria


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