Phytochemical analysis and antidepressant activity of Ixora coccinea extracts in experimental models of depression in miceAjaykumar Rikhabchand Surana1, Rajendra Dayaram Wagh21S.M.B.T.College of Pharmacy, Dhamangaon, Tal-igatpuri, Dist-nashik, M.s.422403 2A.R.A. College of Pharmacy, Dhule, M.S- 424 005
Objectives: Present study deals to access the antidepressant activity of Ixora coccinea extracts in mice and phytochemical analysis of active extract by GC-MS. Materials and Methods: After oral administration of extracts, tail suspension test (TST), force swim tests (FST) and open field test (OFT) were performed to assess the antidepressant activity. GC-MS analysis of methanol extract of Ixora coccinea was performed to find out the chemical constituents in bioactive extract. Results: The methanol extract of I. coccinea at dose of 100 and 200 mg/kg body weight, p.o. significantly reduced the total duration of immobility in the TST as well as FST (P<0.01). I. coccinea extracts not showed any significant changes in locomotor activity in OFT. Conclusion: The methanol extract of I. coccinea possesses antidepressant-like properties in mice without any significant effect on locomotor activity in OFT. Keywords: Antidepressant activity, forced swim test, GC-MS, Ixora coccinea, open field test, tail suspension test
Ajaykumar Rikhabchand Surana, Rajendra Dayaram Wagh. Phytochemical analysis and antidepressant activity of Ixora coccinea extracts in experimental models of depression in mice. . 2018; 15(2): 0-0
Corresponding Author: Ajaykumar Rikhabchand Surana, India |
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