Pre-Treatment Inflammatory and Immune System Parameters to Predict Cervical Cancer Metastasis

Objective: This study aims to evaluate the relationship between Mannose-binding Lectin Associated Serine Protease (MASP)-2 as immune system parameters and Neutrophil Lymphocyte Ratio (NLR) as inflammatory parameters to predict cervical cancer metastasis.
Materials and methods: A cross-sectional study with a total of 80 patients that was diagnosed with cervical cancer between January 2022 to February 2023 at Dr. Wahidin Sudirohusodo Hospital, Hasanuddin University Hospital and Ibnu Sina Hospital, Makassar, Indonesia. Blood samples taken prior to therapy as well as clinical and histological data were gathered and examined. MASP-2 levels and NLR were measured with ELISA and flow cytometry analysis, respectively.
Results: The median age of the patient was 46 years old (24 – 72 years old), with the majority of patients aged between 41 and 52 years old. The statistical analysis showed that MASP-2 had associated with cervical cancer stage (p = <0.000), organ metastasis (p = 0.011) and lymphovascular invasion (p = 0.036). In addition, NLR had associated with the cervical cancer stage (p = 0.004), histopathology type (p = 0.031), tumor size (p= 0.019), and organ metastasis (p = 0.013) in cervical cancer.
Conclusion: Pretreatment MASP-2 as immune systems parameters and NLR as inflammatory parameters associated with cervical cancer metastasis. The NLR indicator can be applied in clinical practice because it is simple and reasonably priced.