. 2007; 4(4): 237-245 | |||
Old and new aspects in the pathophysiology of pre-eclampsiaFederico Prefumo1, Melih Atahan Güven21University Of Brescia, Department Of Obstetrics And Gynaecology, Maternal-fetal Medicine Unit, Brescia, Italy2Anatolia Advanced Level Ultrasonography Center, Perinatology, Ankara, Turkey Pre-eclampsia is a condition affecting the feto-placental unit and the mother. Three to five percent of pregnancies are complicated by pre-eclampsia, a multisystem disorder characterized by hypertension and proteinuria that occurs after 20 weeks of pregnancy. Pre-eclampsia is associated with substantial risks. For the fetus, these include intrauterine growth restriction, death, and prematurity with attendant complications, whereas the mother is at risk for complications of widespread alterations in endothelial function such as seizures (eclampsia), renal failure, pulmonary edema, stroke, and death. The establishment of pathological uterine perfusion raises the problem of stage two. The problem at stage three describes pre-eclampsia as a syndrome with the global maternal endothelial damage as the central pathophysiological feature. Pre-eklampsinin patofizyolojisinde eski ve yeni görüşlerFederico Prefumo1, Melih Atahan Güven21Brescia Üniversitesi, Kadın Hastalıkları Ve Doğum Bölümü, Fetal Tıp Bölümü, Brescia, Italya2Anatolia Ileri Düzey Ultrasonografi Merkezi, Perinatoloji, Ankara, Türkiye Pre-eklampsi; feto-plasental üniteyi ve anneyi etkileyen, 20. gebelik haftasından sonra gebelerin %3-5’ni komplike eden, hipertansiyon ve proteinüri ile seyreden bir durumdur. Pre-eklampsi fetüs ve anne için önemli risklerle ilişkili olup; fetüste intrauterin gelişme geriliği, ölüm ve prematüriteye, anne de ise endotelyal hasara bağlı eklampsi, renal yetmezlik, pulmoner ödem, inme ve de ölüme sebep olabilmektedir. Federico Prefumo, Melih Atahan Güven. Old and new aspects in the pathophysiology of pre-eclampsia. . 2007; 4(4): 237-245 Corresponding Author: Melih Atahan Güven, Türkiye |
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