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Individual effects of GSTM1 and GSTT1 polymorphisms on the risk of polycystic ovarian syndrome: a systematic review and meta-analysisMasoud Hassanzadeh Makoui1, Shiva Fekri2, Reza Hassanzadeh Makoui3, Negar Ansari41Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran2Department of Gynecology and Obstetrics, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran 3Department of Cardiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran 4Department of Internal Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Objective: Polycystic ovarian syndrome (PCOS) is one of the most common endocrinologic disorders in women. It is widely believed that oxidative stress plays a significant role in the pathophysiology of PCOS. The glutathione S-transferases (GST) are a class of enzymes that safeguard cells against oxidative stress. However, published research on the correlation between the GSTT1 and GSTM1 polymorphisms and the risk of PCOS has yielded conflicting results. That’s why a meta-analysis was carried out to evaluate the effects of GSTT1 and GSTM1 polymorphisms on PCOS. Masoud Hassanzadeh Makoui, Shiva Fekri, Reza Hassanzadeh Makoui, Negar Ansari. Individual effects of GSTM1 and GSTT1 polymorphisms on the risk of polycystic ovarian syndrome: a systematic review and meta-analysis. . 2023; 20(4): 0-0 Corresponding Author: Shiva Fekri, Iran |
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