. 2018; 15(2): 80-86

Visfatin as a predictor for growth of fetus and infant

Ashraf Saber Mashhad Taraqi1, Najmeh Tehranian2, Shiva Pourali Roudbaneh6, Matin Sadat Esmaeilzadeh7, Anoshirvan Kazemnejad5, Marzieh Faghani Aghoozi3, Somayeh Yousefi4
1N.T.: Associate Professor, Ph. D in Physiology, Department of Midwifery and Reproductive Health, Faculty of Medical Sciecnes, Tarbiat Modares university,Tehran, Iran
2A.S.: The Corresponding Author: M.Sc in Midwifery, faculty member, Department of Midwifery, Bojnurd Faculty of Nursing & Midwifery, North Khorasan University of Medical Sciences, Bojnurd, Shahriar St, South Side of Imam Ali Hospital, Iran
3S.P.R.: M.Sc in Midwifery, faculty member, Department of Midwifery, School of nursing, Midwifery and Paramedicine, Guilan University of Medical Sciences, Rasht, Iran
4M.S.S.: M.Sc in Midwifery, faculty member, Department of Midwifery, School of nursing, Midwifery and Paramedicine, Guilan University of Medical Sciences, Rasht, Iran
5A.K.: Professor of Biostatistics, Department of Biostatistics, Faculty of Medical Sciences,Tarbiat Modares University, Tehran, IRAN.
6M.F.A.: M.Sc in Midwifery, faculty member, Department of Midwifery, School of nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran
7S.Y.: 7. M.Sc in Midwifery, faculty member, Department of Midwifery, School of nursing and Midwifery, Birjand University of Medical Sciences, Birjand, Iran

Background: Visfatin is an adipocytokine that functions not only as an enzyme, but also as an growth factor
Aim: The present study was conducted with the aim to investigate the relationship between serum visfatin and the fetus 's anthropometric markers up to a year after birth.
Methods: 41 eligible pregnant women in their first trimester were divided and matched in terms of BMI before pregnancy into normal and higher than normal BMI groups A and B. Serum visfatin level was measured during 6-12 and 15-20 weeks of gestation using ELISA method.
Results: The children were followed up for a mean duration of 10.19±2.83 months. In group A, a nearly positive significant relationship was observed between birth head circumference and the first (P1=0.054, r1= 0.580) and second trimester visfatin levels (P2=0.051, r2=0.530). In group B, second trimester visfatin level correlated negatively with birth length (P=0.015,r= - 0.523) and infant's head circumference (nearly significant; (P2=0.050, r2= - 0.392). In a separate study on group B, visfatin levels in the first and second trimesters showed a negative significant correlation with infant’s weight. A significant correlation was observed between the first and second trimesters visfatin level with infant’s height in both groups, such that this relationship was positive in group A and negative in group B. Lenear regression analysis revealed that first and second trimester visfatin levels were the significant independent predictors of infant’s weight in group B and infant’s height in both groups. second trimester visfatin level was the significant predictor of birth height in group B.
Conclusion: Maternal serum visfatin level shows a relationship with the fetal and the children’s anthropometric indicators, with different effects in the two groups, suggesting visfatin dysfunction in the overweight group before pregnancy.

Keywords: visfatin, predictor, grow, fetus, Infant


Ashraf Saber Mashhad Taraqi, Najmeh Tehranian, Shiva Pourali Roudbaneh, Matin Sadat Esmaeilzadeh, Anoshirvan Kazemnejad, Marzieh Faghani Aghoozi, Somayeh Yousefi. Visfatin as a predictor for growth of fetus and infant. . 2018; 15(2): 80-86

Corresponding Author: Ashraf Saber Mashhad Taraqi, Iran


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