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Effect of Metformin on Proliferative Markers in Women with Endometrial Carcinoma: Systematic review and meta-analysisMohammad Abrar Shareef1, Ahmed Adel Sofy2, Ahmed Taha Abdelsattar2, Ahmed Taher Masoud2, Abdullah Mohamed Farhat2, Hiba Maarouf31Department of Internal Medicine, Sebasticook Valley Hospital, Pittsfield, ME, USA2Faculty Of Medicine, Fayoum University, Fayoum, Egypt. 3REProVita Fertility Center, Hertener Str. 29, 45657 Recklinghausen, Germany Endometrial carcinoma (EC) is the most common gynecologic malignancy in the USA and Western Europe. Surgery is the mainstay of both staging and treatment of EC. Fertility sparing medical therapies are often offered to young women who desire fertility. Metformin has been suggested to be an anti-cancer agent as evidenced by previous studies. It decreases Antigen Ki-67 (Ki-67) proliferation and expression which is associated with proliferative activity of malignant tumors. In this systematic review and meta-analysis, we aimed to assess the efficacy of metformin on patients with EC. Mohammad Abrar Shareef, Ahmed Adel Sofy, Ahmed Taha Abdelsattar, Ahmed Taher Masoud, Abdullah Mohamed Farhat, Hiba Maarouf. Effect of Metformin on Proliferative Markers in Women with Endometrial Carcinoma: Systematic review and meta-analysis. . 2022; 19(1): 0-0 Corresponding Author: Abdullah Mohamed Farhat, Egypt |
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