. 2017; 14(2): 106-113

Maternal and fetal outcomes in pregnant women with Hepatitis E infection: still an important fetomaternal killer with an unresolved mystery of increased virulence in pregnancy.

Namrata Kumar, Vinita Das, Anjoo Agarwal, Amita Pandey, Smriti Agrawal
Department Of Obstetrics and Gynecology, King George

INTRODUCTION
Hepatitis is a prevalent infection in developing countries. While hepatitis B and C are deepening their roots in developed world, hepatitis A and E are common in developing world. The uniqueness of hepatitis is in a way of its transformation from a relatively self limiting disease in non pregnant state to a highly virulent disease in pregnancy.
METHOD
This retrospective observational study was conducted in the Department of Obstetrics and Gynecology, King George’s Medical University, Lucknow for a period of six months during an endemic of HEV ( June 2016 to November 2016) to observe the clinical outcomes in HEV infected pregnant women.
RESULTS
A total of 32 Anti-HEV IgM-positive women were included, and the maternal-fetal outcome was analyzed. Hepatitis E positivity was significantly associated with maternal mortality, intrauterine demise with prematurity and premature rupture of membranes being the commonest fetal complications noted.
CONCLUSION
Difference in extent of virulence of infection and variations in maternal morbidity, mortality and rates of intrauterine demise signify some factors which play role and need to be further studied and evaluated.

Keywords: KEYWORDS- encephalopathy, hepatitis B, hepatitis E, jaundice, pregnancy, outcome.


Maternal and fetal outcomes in pregnant women with Hepatitis E infection: still an important fetomaternal killer with an unresolved mystery of increased virulence in pregnancy.

Namrata Kumar, Vinita Das, Anjoo Agarwal, Amita Pandey, Smriti Agrawal
Department Of Obstetrics and Gynecology, King George

INTRODUCTION
Hepatitis is a prevalent infection in developing countries. While hepatitis B and C are deepening their roots in developed world, hepatitis A and E are common in developing world. The uniqueness of hepatitis is in a way of its transformation from a relatively self limiting disease in non pregnant state to a highly virulent disease in pregnancy.
METHOD
This retrospective observational study was conducted in the Department of Obstetrics and Gynecology, King George’s Medical University, Lucknow for a period of six months during an endemic of HEV ( June 2016 to November 2016) to observe the clinical outcomes in HEV infected pregnant women.
RESULTS
A total of 32 Anti-HEV IgM-positive women were included, and the maternal-fetal outcome was analyzed. Hepatitis E positivity was significantly associated with maternal mortality, intrauterine demise with prematurity and premature rupture of membranes being the commonest fetal complications noted.
CONCLUSION
Difference in extent of virulence of infection and variations in maternal morbidity, mortality and rates of intrauterine demise signify some factors which play role and need to be further studied and evaluated.

Anahtar Kelimeler: KEYWORDS- encephalopathy, hepatitis B, hepatitis E, jaundice, pregnancy, outcome.


Namrata Kumar, Vinita Das, Anjoo Agarwal, Amita Pandey, Smriti Agrawal. Maternal and fetal outcomes in pregnant women with Hepatitis E infection: still an important fetomaternal killer with an unresolved mystery of increased virulence in pregnancy.. . 2017; 14(2): 106-113

Corresponding Author: Namrata Kumar, India


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