IgG4 deficiency can be a new entity for primary recurrent miscarriage: Successful pregnancy in two cases after treatment with intravenous immunoglobulin

Recurrent miscarriage is one of the complications during pregnancy in which the potential role of immunologic factors has already mentioned.
Here, two young women with recurrent miscarriage were consulted in the infertility center. The diagnosis of IgG4 deficiency was made by the reduction of IgG4 immunoglobulin levels and normal total IgG titer. Considering this abnormality, intravenous immunoglobulin 200 mg/ kg started monthly, they had successful pregnancies.
Up to now, only little is known about the IgG4 deficiency in women with recurrent miscarriage. IgG4 deficiency should be taken into account in these patients, it is expected that the results will shed further light on the feasibility of intravenous immunoglobulin for women with recurrent miscarriage.