. 2019; 49(6): 334-341

Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal Detachment

Chafik Keilani1, Edouard Augstburger3, Mathieu Robin3, Amélie Beaugrand4, Raphaëlle Ores2, José-Alain Sahel2, Sarah Ayello - Scheer2
1Department of Ophthalmology IV, Quinze-Vingts National Hospital. 28 Rue de Charenton, 75 571 Paris, FRANCE / Faculty of medicine Pierre-et-Marie-Curie, Sorbonne University, Paris VI, 91—105, boulevard de l’Hopital, 75013 Paris, FRANCE / Assistance Publique—Hopitaux de Paris, 75004 Paris, FRANCE
2Department of Ophthalmology IV, Quinze-Vingts National Hospital. 28 Rue de Charenton, 75 571 Paris, FRANCE
3Department of Ophthalmology III, Quinze-Vingts National Hospital. 28 Rue de Charenton, 75 571 Paris, FRANCE.
4Department of Biomedical Informatics, Quinze-Vingts National Hospital. 28 Rue de Charenton, 75 571 Paris, FRANCE.

OBJECTIVE. To compare biochemical outcomes, effectiveness and tolerance of two high-density silicone oils (HDSO), silicone oil-RMN3 (Oxane® HD) and silicone oil-Densiron-68 (Densiron®68), for the management of complicated retinal detachment (RD) associated with inferior proliferative vitreoretinopathy (PVR).
METHODS. Retrospective, single-centre, comparative case series of 23 patients treated between September 2014 and June 2016. The main inclusion criteria was RD with inferior PVR receiving Oxane® HD or Densiron® 68 following pars plana vitrectomy. The main outcome measures were anatomical success, the rate of RD recurrence and best-corrected visual acuity (BCVA) at 6 months. Secondary outcomes were short term complications.
RESULTS. 23 eyes were included: 16 eyes undergoing Densiron® 68 tamponade and 7 eyes undergoing Oxane® HD tamponade. Anatomical success under HDSO was statistically significantly higher in the Densiron® 68 group (100 %) than in the Oxane® HD group (42.8 %) (p = 0.0455). Recurrent RD was observed in 42.8 % of eyes under Oxane® HD, but in none of the patients under Densiron® 68 (p = 0,001). Six months after surgery, mean BVCA values (+/- Standard Deviation SD) were 0.83 ± 0.62 logMAR units and 1.81 ± 0.65 logMAR units with Densiron® 68 and Oxane® HD, respectively. BVCA was statistically significantly higher in the Densiron® 68 group (p = 0.006). No significant differences were observed with regard to intraocular pressure, emulsification, and intraocular inflammation.
CONCLUSION. Densiron® 68 appears more effective than Oxane® HD for the management of RD associated with PVR. A randomized, controlled, interventional study is needed to demonstrate this difference.

Keywords: High-density silicone oils, Densiron® 68, Oxane® HD, Complicated inferior retinal detachment, Proliferative vitreoretinopathy


Chafik Keilani, Edouard Augstburger, Mathieu Robin, Amélie Beaugrand, Raphaëlle Ores, José-Alain Sahel, Sarah Ayello - Scheer. Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal Detachment. . 2019; 49(6): 334-341

Sorumlu Yazar: Chafik Keilani, France


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