Is glaucoma a two-pressure related optic neuropathy?
Tung Thanh Hoang1, Tung Thanh Hoang2, Tung Thanh Hoang3, BUI VAN ANH4, Prem Subramanian51Ophthalmology Department, Hanoi Medical University, Vietnam2Ophthalmology Division, Hanoi Medical University Hospital, Vietnam
3Save Sight Institute, The University of Sydney School of Medicine, Australia
4Glaucoma Department, Vietnam National Eye Hospital, Vietnam
5Ophthalmology Department, University of Colorado School of Medicine, USA
ABSTRACT
Objective
To review the current literature related to the correlation between translaminar pressure difference (TLPD) and glaucoma.
Materials and Methods
In this article, we conducted the literature review, using MEDLINE through Pubmed, Cochrane Vision Eyes and Visions and Google Scholar from 01/01/2010 to 31/12/2022. Search term included “glaucoma”, “intraocular pressure”, “translaminar cribrosa pressure gradient/difference”, “intracranial pressure”, “cerebrospinal fluid pressure”. Eight articles were selected from 471 results for meta-analysis.
Results
Our meta-analysis found significant higher IOP, lower CSFp and higher TLPD in high tension and normal tension glaucoma groups compared to healthy groups.
Conclusions
The CSFp and TLPD differences between glaucoma and healthy people demonstrated the potential relationship between TLPD and glaucoma showned by current studies.
Key words: glaucoma, intraocular pressure, translaminar cibrosa pressure gradient/difference, cerebrospinal fluid pressure, intracranial pressure
Corresponding Author: Tung Thanh Hoang, Vietnam
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