. 2013; 30(1): 13-18 | DOI: 10.4274/tjh.98474 | |||
Miyeloproliferatif Neoplazmlar ve Sekonder Eritrositoz/Trombositemide SOCS3 MetilasyonuDeniz Torun1, Oral Nevruz2, Mesut Akyol3, Salih Kozan1, Muhterem Bahçe1, Şefik Güran4, Cengiz Beyan21Gülhane Askeri Tıp Fakultesi, Tıbbi Genetik Bilim Dalı, Ankara2Gülhane Askeri Tıp Fakultesi, Hematoloji Bilim Dalı, Ankara 3Gülhane Askeri Tıp Fakultesi, Biyoistatistik Bilim Dalı, Ankara 4Gülhane Askeri Tıp Fakultesi, Tıbbi Biyoloji Ana Bilim Dalı, Ankara AMAÇ: Esansiyel trombositemi (ET), polisitemia vera (PV), primer miyelofibrozis (PMF) gibi miyeloproliferatif neoplazmlar (MPN) kazanılmış klonal hematopoetik kök hücre hastalığı olup multipotent hematopoietik kök hücreden köken alırlar. SOCS1 ve SOCS3 genleri JAK/STAT sinyal yolağının negatif düzenleyicileridir. Bu çalışmada MPN ve sekonder eritrositoz/trombositemi patogenezinde bu genlerin promotor metilasyonunu incelemeyi amaçladık. Methylation of SOCS3 in Myeloproliferative Neoplasms and Secondary Erythrocytosis/ThrombocythemiaDeniz Torun1, Oral Nevruz2, Mesut Akyol3, Salih Kozan1, Muhterem Bahçe1, Şefik Güran4, Cengiz Beyan21Gülhane Military Medical Faculty, Department Of Medical Genetics, Ankara, Turkey2Gülhane Military Medical Faculty, Department Of Hematology, Ankara, Turkey 3Gülhane Military Medical Faculty, Department Of Biostatistics, Ankara, Turkey 4Gülhane Military Medical Faculty, Department Of Medical Biology, Ankara, Turkey OBJECTIVE: Myeloproliferative neoplasms (MPNs) like essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF) are acquired clonal hematopoietic stem cell disorders and originate from a multipotent hematopoietic stem cell. The SOCS1 and SOCS3 genes are negative regulators of the JAK/STAT signal pathway. In this study we investigate the promoter methylation of these genes in the pathogenesis of MPNs and secondary erythrocytosis/thrombocythemia. Deniz Torun, Oral Nevruz, Mesut Akyol, Salih Kozan, Muhterem Bahçe, Şefik Güran, Cengiz Beyan. Methylation of SOCS3 in Myeloproliferative Neoplasms and Secondary Erythrocytosis/Thrombocythemia. . 2013; 30(1): 13-18 Sorumlu Yazar: Deniz Torun, Türkiye |
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