Extramedullary Presentation of Biclonal IgGk and IgAk Multiple Myeloma
Güçhan Alanoğlu1, Gülsüm Özet2, Klara Dalva3, Işınsu Kuzu4, Selim Erekul4, Osman İlhan3, Meral Beksaç31Department Of Haematology, Ankara Hospital, Ankara, Turkey2Department Of Haematology, Ankara Numune Hospital, Ankara, Turkey
3Department Of Haematology, Medical Faculty, University Of Ankara, İbn-i Sina Hospital, Ankara, Turkey
4Department Of Pathology, Medical Faculty, University Of Ankara, İbn-i Sina Hospital, Ankara, Turkey
Multiple myeloma is characterized by plasma cell infiltration of the bone marrow and the presence of a monoclonal protein in the plasma or the urine in 90% of cases. Major manifestations of the disease are bone pain, anemia, renal insufficiency and recurrent infections. Less frequent presentations are hepatic and splenic enlargement (5% of cases), lymphadenopathy (4%) and biclonal gammopathy (1%). In this report we describe a biclonal multiple myeloma presenting with cervical lymphadenopathy and sternal mass. The immunohistochemical study of the lymph node and the flow cytometric analysis of the bone marrow showed IgGk and IgAk biclonality. In this report the features of lymph node involvement and biclonality constitute a rare presentation of multiple myeloma.
Keywords: Multiple myeloma, Extramedullary myeloma, Lymphadenopathy, Biclonal gammopathy. Turk J Haematol 2002, 19(3): 421-425Sorumlu Yazar: Güçhan Alanoğlu, Türkiye
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