. 2016; 33(3): 180-186 | DOI: 10.4274/tjh.2015.0220 | |||
Miyeloproliferatif Neoplazisi ve Akut Lösemisi Olan Hastalarda Kalretikülin Mutasyon ProfiliJingyi Wang1, Jianguo Hao3, Na He2, Chunyan Ji1, Daoxin Ma11Qilu Hospital of Shandong University, Department of Hematology, Shandong, China2Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Department of Hematology, Shandong, China 3General Hospital of Shandong Stell Group Company, Department of Surgery, Shandong, China Amaç: Kalretikülin (CALR) hücre çoğalması, apoptoz ve immün yanıtlarda önemli rol oynar. CALR mutasyonları yakın zamanda Janus kinaz 2 (JAK2) veya MPL geni negatif primer miyelofibroz (PMF) ve esansiyel trombositemi (ET) hastalarında tanımlanmıştır. CALR JAK2’yi takiben miyeloproliferatif neoplazilerde (MPN) ikinci sıklıkta görülen mutant gendir. Ancak, Çinli lösemi hastalarında CALR mutasyonları hakkında bilgi sınırlıdır. Bu çalışmada, hematopoetik neoplazisi olan 305 Çinli hasta CALR mutasyonları, bu mutasyonların lösemi ve MPN hastalarındaki sıklığının ortaya çıkarılması için taranmıştır. The Mutation Profile of Calreticulin in Patients with Myeloproliferative Neoplasms and Acute LeukemiaJingyi Wang1, Jianguo Hao3, Na He2, Chunyan Ji1, Daoxin Ma11Qilu Hospital of Shandong University, Department of Hematology, Shandong, China2Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Department of Hematology, Shandong, China 3General Hospital of Shandong Stell Group Company, Department of Surgery, Shandong, China Objective: Calreticulin (CALR) plays important roles in cell proliferation, apoptosis, and immune responses. CALR mutations were described recently in Janus kinase 2 gene (JAK2)-negative or MPLnegative primary myelofibrosis (PMF) and essential thrombocythemia (ET) patients. CALR trails JAK2 as the second most mutated gene in myeloproliferative neoplasms (MPNs). However, little is known about CALR mutation in Chinese patients with leukemia. In the present study, a cohort of 305 Chinese patients with hematopoietic neoplasms was screened for CALR mutations, with the aim of uncovering the frequency of CALR mutations in leukemia and MPNs. Jingyi Wang, Jianguo Hao, Na He, Chunyan Ji, Daoxin Ma. The Mutation Profile of Calreticulin in Patients with Myeloproliferative Neoplasms and Acute Leukemia. . 2016; 33(3): 180-186 Sorumlu Yazar: Daoxin Ma, China |
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