. 2015; 32(2): 127-135 | DOI: 10.4274/Tjh.2013.0296 | |||
WNT5A Hipermetilasyonun Çocukluk Çağı Akut Lenfoblastik Lösemideki Olası RolüÖzden Hatırnaz Ng1, Sinem Fırtına1, İsmail Can1, Zeynep Karakaş2, Leyla Ağaoğlu2, Ömer Doğru3, Tiraje Celkan4, Arzu Akçay5, Yıldız Yıldırmak6, Çetin Timur7, Uğur Özbek1, Müge Sayitoğlu11İstanbul University Faculty of Medicine, Institute of Experimental Medicine Research (DETAE), Department of Genetics, İstanbul, Turkey2stanbul University İstanbul Faculty of Medicine, Department of Pediatric Hematology and Oncology, İstanbul, Turkey 3Akdeniz University Faculty of Medicine, Department of Pediatric Hematology and Oncology, Antalya, Turkey 4İstanbul University Cerrahpaşa Faculty of Medicine, Department of Pediatric Hematology and Oncology, İstanbul, Turkey 5Kanuni Sultan Süleyman Research and Training Hospital, Clinic of Pediatric Hematology and Oncology, İstanbul, Turkey 6Şişli Etfal Research and Training Hospital, Clinic of Pediatric Hematology and Oncology, İstanbul, Turkey 7Medeniyet University Faculty of Medicine, Göztepe Research and Training Hospital, Clinic of Pediatric Hematology and Oncology, İstanbul, Turkey GİRİŞ ve AMAÇ: WNT5A, kanonik olmayan WNT ligandlarının en çok çalışılanıdır ve farklı tümör tiplerinde fonksiyon bozukluğu gösterdiği bilinmektedir. Amacımız tespit edilen düşük WNT5A mRNA miktarının altında yatan sebebin hiper metilasyon olup olmadığını açıklığa kavuşturmak ve bu düşüşü hiper metilasyonu tersine çevirerek düzeltip düzeltemeyeceğimizi belirlemekti. A possible role for WNT5A hypermethylation in Pediatric Acute Lymphoblastic LeukemiaÖzden Hatırnaz Ng1, Sinem Fırtına1, İsmail Can1, Zeynep Karakaş2, Leyla Ağaoğlu2, Ömer Doğru3, Tiraje Celkan4, Arzu Akçay5, Yıldız Yıldırmak6, Çetin Timur7, Uğur Özbek1, Müge Sayitoğlu11İstanbul University Faculty of Medicine, Institute of Experimental Medicine Research (DETAE), Department of Genetics, İstanbul, Turkey2stanbul University İstanbul Faculty of Medicine, Department of Pediatric Hematology and Oncology, İstanbul, Turkey 3Akdeniz University Faculty of Medicine, Department of Pediatric Hematology and Oncology, Antalya, Turkey 4İstanbul University Cerrahpaşa Faculty of Medicine, Department of Pediatric Hematology and Oncology, İstanbul, Turkey 5Kanuni Sultan Süleyman Research and Training Hospital, Clinic of Pediatric Hematology and Oncology, İstanbul, Turkey 6Şişli Etfal Research and Training Hospital, Clinic of Pediatric Hematology and Oncology, İstanbul, Turkey 7Medeniyet University Faculty of Medicine, Göztepe Research and Training Hospital, Clinic of Pediatric Hematology and Oncology, İstanbul, Turkey INTRODUCTION: WNT5A is one of the most studied noncanonical WNT ligands and is shown to be deregulated in different tumor types. Our aim was to clarify whether hypermethylation might be the cause of low WNT5A mRNA levels and whether we could restore this downregulation by reversing the event. Özden Hatırnaz Ng, Sinem Fırtına, İsmail Can, Zeynep Karakaş, Leyla Ağaoğlu, Ömer Doğru, Tiraje Celkan, Arzu Akçay, Yıldız Yıldırmak, Çetin Timur, Uğur Özbek, Müge Sayitoğlu. A possible role for WNT5A hypermethylation in Pediatric Acute Lymphoblastic Leukemia. . 2015; 32(2): 127-135 Sorumlu Yazar: Müge Sayitoğlu, Türkiye |
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