Monozomal Karyotipi Olan Akut Miyeloid Lösemili Hastalarda Kötü Prognoz

Xu, Junqing; Huang, Baohua; Liu, Xiaoqian; Zhang, Yuanfeng; Liu, Yinghui; Chen, Liming; Luan, Yanyan; Li, Nannan; Chu, Xiaoxia

Junqing Xu¹, Baohua Huang², Xiaoqian Liu¹, Yuanfeng Zhang¹, Yinghui Liu¹, Liming Chen¹, Yanyan Luan¹, Nannan Li¹, Xiaoxia Chu¹

¹Qindao University Medical College, Affiliated Yantai Yuhuangding Hospital, Department of Hematology, Yantai, China
²Qindao University Medical College, Affiliated Yantai Yuhuangding Hospital, Laboratory of Hematology, Yantai, China

Amaç: Bu çalışmada akut myeloid lösemi (AML) hastalarında monozomal karyotipe (MK) sahip olmanın klinik özellikleri ve prognostik önemini araştırmak hedeflenmiştir.
Gereç ve Yöntem: Retrospektif olarak 498 AML hastasının klinik verileri incelenmiştir. Bu hastalardan 233’ünde (%46,8) anormal karyotip saptanmış olup, bunların da 42’sinde (%8,4) MK ve 70’inde kompleks karyotip (KK) bulunmuştur.
Bulgular: Hastalardan MK’ya sahip olanlar daha yaşlı olup (ortanca 62,5 vs. 52 yıl; p=0,003), daha düşük ortanca hemoglobin düzeyine (62,5 vs. 77 g/L; p=0,009) ve daha düşük beyaz küre sayısına (7,0×109/L vs. 11,7×109/L, p=0,008) sahipti. Ünivaryant analizde MK ya da KK’ya sahip olan hastaların diğer hastalara göre toplam sağkalımı daha düşük bulundu. (MK için ortanca sağkalım süresi 7,3 vs. 26,3 ay, p<0,001 ve CK için 14,8 vs. 26,3 ay, p<0,001). Toplam sağkalım için yapılan, multivaryant analizde ise MK ve “National Comprehesnsive Cancer Network” prognostik grubu anlamlı bulunan faktörlerdi.
Sonuç: AML’li hastalarda MK kötü prognoza işaret eden bağımsız bir risk faktörüdür.

Anahtar Kelimeler:

Poor Prognosis in Acute Myeloid Leukemia Patients with Monosomal Karyotype

Junqing Xu¹, Baohua Huang², Xiaoqian Liu¹, Yuanfeng Zhang¹, Yinghui Liu¹, Liming Chen¹, Yanyan Luan¹, Nannan Li¹, Xiaoxia Chu¹

Objective: This study aimed to investigate the clinical characteristics and prognostic significance of monosomal karyotypes (MKs) in patients with acute myeloid leukemia (AML).
Materials and Methods: We retrospectively analyzed the clinical data for 498 patients with AML, of whom 233 (46.8%) had an abnormal karyotype, including 42 with MKs (8.4%) and 70 with a complex karyotype (CK) (14.1%).
Results: Patients with MKs were older (median age 62.5 vs. 52 years, p=0.003) and had lower median hemoglobin levels (62.5 vs. 77 g/L, p=0.009) and lower white blood cell counts (7.0×109/L vs. 11.7×109/L, p=0.008). Univariate analysis showed that patients with MKs or CKs had shorter overall survival than patients without these karyotypes (median survival time 7.3 vs. 26.3 months for MK, p<0.001, and 14.8 vs. 26.3 months for CK, p<0.001). In multivariable analysis for overall survival, MK and National Comprehensive Cancer Network prognostic group were the only significant factors.
Conclusion: MK is an independent risk factor for poor prognosis in AML patients.

Keywords:

Junqing Xu, Baohua Huang, Xiaoqian Liu, Yuanfeng Zhang, Yinghui Liu, Liming Chen, Yanyan Luan, Nannan Li, Xiaoxia Chu. Poor Prognosis in Acute Myeloid Leukemia Patients with Monosomal Karyotype. . 2017; 34(2): 126-130

Sorumlu Yazar: Xiaoxia Chu, China