. 2020; 37(2): 98-103 | DOI: 10.4274/tjh.galenos.2019.2019.0282 | |||
Çocukluk Çağı T-hücreli Akut Lenfoblastik Lösemi Hastalarında PTEN ve AKT1 VaryasyonlarFulya Küçükcankurt1, Yücel Erbilgin2, Sinem Fırtına3, Özden Hatırnaz Ng4, Zeynep Karakaş5, Tiraje Celkan6, Ayşegül Ünüvar5, Uğur Özbek7, Müge Sayitoğlu21İstanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Genetics, Istanbul, Turkey; Altınbaş University, Faculty of Medicine, Istanbul, Turkey2İstanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Genetics, Istanbul, Turkey 3İstanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Genetics, Istanbul, Turkey; İstinye University, Faculty of Art and Science, Department of Molecular Biology and Genetics, İstanbul, Turkey 4İstanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Genetics, Istanbul, Turkey; Acıbadem Mehmet Ali Aydınlar University School of Medicine, Department of Medical Biology, Istanbul, Turkey 5İstanbul University, School of Medicine, Department of Pediatrics Hematology, Istanbul, Turkey 6Istanbul University-Cerrahpaşa School of Medicine, Department of Pediatrics Hematology, Istanbul, Turkey 7İstanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Genetics, Istanbul, Turkey; Acıbadem Mehmet Ali Aydınlar University School of Medicine, Department of Medical Genetics, Istanbul, Turkey Amaç: PTEN/AKT yolak düzensizliklerinin akut lösemide tedavi yanıtı ile ilişkili olduğu bildirilmiştir. Çalışmanın kapsamı, pediatrik T-ALL hastalarının PTEN ve AKT1 genlerinin sıcak bölge varyasyonları için incelenmesi ve klinik bulgularla değerlendirilmesidir. PTEN and AKT1 Variations in Childhood T-Cell Acute Lymphoblastic LeukemiaFulya Küçükcankurt1, Yücel Erbilgin2, Sinem Fırtına3, Özden Hatırnaz Ng4, Zeynep Karakaş5, Tiraje Celkan6, Ayşegül Ünüvar5, Uğur Özbek7, Müge Sayitoğlu21İstanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Genetics, Istanbul, Turkey; Altınbaş University, Faculty of Medicine, Istanbul, Turkey2İstanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Genetics, Istanbul, Turkey 3İstanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Genetics, Istanbul, Turkey; İstinye University, Faculty of Art and Science, Department of Molecular Biology and Genetics, İstanbul, Turkey 4İstanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Genetics, Istanbul, Turkey; Acıbadem Mehmet Ali Aydınlar University School of Medicine, Department of Medical Biology, Istanbul, Turkey 5İstanbul University, School of Medicine, Department of Pediatrics Hematology, Istanbul, Turkey 6Istanbul University-Cerrahpaşa School of Medicine, Department of Pediatrics Hematology, Istanbul, Turkey 7İstanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Genetics, Istanbul, Turkey; Acıbadem Mehmet Ali Aydınlar University School of Medicine, Department of Medical Genetics, Istanbul, Turkey Objective: PTEN/AKT pathway deregulations have been reported to be associated with treatment response in acute leukemia. This study examined pediatric T-cell acute lymphoblastic leukemia (T-ALL) samples for PTEN and AKT1 gene variations and evaluated the clinical findings. Fulya Küçükcankurt, Yücel Erbilgin, Sinem Fırtına, Özden Hatırnaz Ng, Zeynep Karakaş, Tiraje Celkan, Ayşegül Ünüvar, Uğur Özbek, Müge Sayitoğlu. PTEN and AKT1 Variations in Childhood T-Cell Acute Lymphoblastic Leukemia. . 2020; 37(2): 98-103 Sorumlu Yazar: Müge Sayitoğlu |
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