. 2014; 31(1): 25-31 | DOI: 10.4274/Tjh.2012.0146 | |||
Güney İran’da Eritrosit Zarı Hücre İskelet Bozukluklarının Akım Sitometri ile DeğerlendirilmesiHabib Alah Golafshan1, Reza Ranjbaran1, Tahereh Kalantari1, Leili Moezzi1, Mehran Karimi2, Abbas Behzad- Behbahani1, Farzaneh Aboualizadeh1, Sedigheh Sharifzadeh11Diagnostic Laboratory, Sciences And Research Technology Center, Shiraz University Of Medical Sciences, Shiraz, Iran / School Of Para Medical Sciences, Shiraz University Of Medical Sciences, Shiraz, Iran2Hematology Research Center, Shiraz University Of Medical Sciences, Shiraz, Iran AMAÇ: Kalıtsal eritrosit zarı bozukluklarının ve özellikle kalıtsal sferositoz ve Güneydoğu Asya ovalositozunun tanısı klinik öykü, eritrosit morfolojisi ve ozmotik frajilite gibi konvansiyonel testlere dayanmaktadır. Ancak bu hastalıkların tanı koymada zorlanılan daha hafif formları bulunmaktadır. Eozin-5-malemid’in (EMA) kullanımı diğer anemiler yanında eritrosit zarı bozukluklarının taramasında değerlendirilmiştir. Biz HS gibi bazı zar bozukluklarının değerlendirilmesinde, öncelikle band 3 proteinini ve daha az oranda diğer zar proteinlerini bağlayan, EMA boyasını kullandık. Evaluation of Red Cell Membrane Cytoskeletal Disorders Using a Flow Cytometric Method in South IranHabib Alah Golafshan1, Reza Ranjbaran1, Tahereh Kalantari1, Leili Moezzi1, Mehran Karimi2, Abbas Behzad- Behbahani1, Farzaneh Aboualizadeh1, Sedigheh Sharifzadeh11Diagnostic Laboratory, Sciences And Research Technology Center, Shiraz University Of Medical Sciences, Shiraz, Iran / School Of Para Medical Sciences, Shiraz University Of Medical Sciences, Shiraz, Iran2Hematology Research Center, Shiraz University Of Medical Sciences, Shiraz, Iran OBJECTIVE: The diagnosis of hereditary red blood cell (RBC) membrane disorders, and in particular hereditary spherocytosis (HS) and Southeast Asian ovalocytosis (SAO), is based on clinical history, RBC morphology, and other conventional tests such as osmotic fragility. However, there are some milder cases of these disorders that are difficult to diagnose. The application of eosin-5’-maleimide (EMA) was evaluated for screening of RBC membrane defects along with some other anemias. We used EMA dye, which binds mostly to band 3 protein and to a lesser extent some other membrane proteins, for screening of some membrane defects such as HS. Habib Alah Golafshan, Reza Ranjbaran, Tahereh Kalantari, Leili Moezzi, Mehran Karimi, Abbas Behzad- Behbahani, Farzaneh Aboualizadeh, Sedigheh Sharifzadeh. Evaluation of Red Cell Membrane Cytoskeletal Disorders Using a Flow Cytometric Method in South Iran. . 2014; 31(1): 25-31 Sorumlu Yazar: Sedigheh Sharifzadeh, Iran |
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