. 2019; 36(2): 97-105 | DOI: 10.4274/tjh.galenos.2019.2018.0449 | |||
Trombositlerin Monositlerle Ortak Kültürü ile İndüklenen M2 Makrofaj Polarizasyonu ve Köpük Hücrelerinin Oluşumu: Monosit Farklılaşmasında Trombositlerin Önemli Rolü Üzerine Işık TutmaMahdieh Mehrpouri1, Davood Bashash1, Mohammad Hossien Mohammadi2, Mohammad Esmail Gheydari3, Esmail Shahabi Satlsar1, Mohsen Hamidpour21Shahid Beheshti University of Medical Sciences, Faculty of Allied Medical Sciences, Department of Hematology and Blood Banking, Tehran, Iran2HSCT Research Centre, Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran 3Shahid Beheshti University of Medical Sciences Faculty of Medicine, Taleghani General Hospital, Department of Cardiology, Tehran, Iran Amaç: Hemostaz ve trombozun çok ötesinde, önemli kanıtlar trombositlerin aterosklerozdaki kritik rolüne işaret etmektedir. SDF-1 koroner arter hastalığı (KAH) olan hastaların trombositlerinde artan proenflamatuvar kemokinler arasında yer almaktadır. Bu çalışmanın amacı, KAH olan hastalar ve sağlıklı gönüllülerin trombositlerinin makrofajlar ve köpük hücrelerinin indüksiyonunda in vitro etkilerini belirlemektir. Co-culture of Platelets with Monocytes Induced M2 Macrophage Polarization and Formation of Foam Cells: Shedding Light on the Crucial Role of Platelets in Monocyte DifferentiationMahdieh Mehrpouri1, Davood Bashash1, Mohammad Hossien Mohammadi2, Mohammad Esmail Gheydari3, Esmail Shahabi Satlsar1, Mohsen Hamidpour21Shahid Beheshti University of Medical Sciences, Faculty of Allied Medical Sciences, Department of Hematology and Blood Banking, Tehran, Iran2HSCT Research Centre, Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran 3Shahid Beheshti University of Medical Sciences Faculty of Medicine, Taleghani General Hospital, Department of Cardiology, Tehran, Iran Objective: Far beyond hemostasis and thrombosis, significant evidence has indicated the critical role of platelets in atherosclerosis. SDF-1 is among the pro-inflammatory chemokines that are increased in platelets of patients with coronary artery disease (CAD). The goal of the current work is to identify the in vitro effect of platelets from either CAD patients or healthy volunteers on the induction of macrophages and foam cells. Mahdieh Mehrpouri, Davood Bashash, Mohammad Hossien Mohammadi, Mohammad Esmail Gheydari, Esmail Shahabi Satlsar, Mohsen Hamidpour. Co-culture of Platelets with Monocytes Induced M2 Macrophage Polarization and Formation of Foam Cells: Shedding Light on the Crucial Role of Platelets in Monocyte Differentiation. . 2019; 36(2): 97-105 Sorumlu Yazar: Mohsen Hamidpour, Türkiye |
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