. 2022; 39(1): 22-28 | DOI: 10.4274/tjh.galenos.2021.2021.0054 | |||
Glutamin Yoksunluğuna Dirençli Lösemi Hücreleri Glutamin Sentetaz Proteini Eksprese EderBurcu Yücel1, Saniye Ada21İstanbul Medeniyet University Faculty of Medicine, Department of Medical Biology, İstanbul, Turkey; İstanbul Medeniyet University, Science and Advanced Technologies Research Center (BILTAM), İstanbul, Turkey; Health Institutes of Turkey (TUSEB), Turkish Biotechnology Institute, İstanbul, Turkey2İstanbul Medeniyet University, Science and Advanced Technologies Research Center (BILTAM), İstanbul, Turkey; İstanbul Medeniyet University Faculty of Medicine, Department of Medical Biochemistry, İstanbul, Turkey Amaç: Farklı kanser alt tiplerinde tümör çevresinde düşük glutamin seviyeleri gösterilmiştir. Bu nedenle, kanser hücrelerinin hayatta kalmak ve çoğalabilmek için düşük besin seviyelerinde metabolizmalarını yeniden yapılandırdığı öne sürülmüştür. Glutamin esansiyel olmayan bir amino asit olmasına ve de novo sentezlenebilmesine rağmen, malign hematopoietik hücreler de dahil olmak üzere birçok kanser hücresinin glutamine bağımlı olduğu belirtilmiştir. Bu çalışmada lösemi hücre hatlarının glutaminden yoksun koşullarda çoğalmasının araştırılması amaçlandı. Leukemia Cells Resistant to Glutamine Deprivation Express Glutamine Synthetase ProteinBurcu Yücel1, Saniye Ada21İstanbul Medeniyet University Faculty of Medicine, Department of Medical Biology, İstanbul, Turkey; İstanbul Medeniyet University, Science and Advanced Technologies Research Center (BILTAM), İstanbul, Turkey; Health Institutes of Turkey (TUSEB), Turkish Biotechnology Institute, İstanbul, Turkey2İstanbul Medeniyet University, Science and Advanced Technologies Research Center (BILTAM), İstanbul, Turkey; İstanbul Medeniyet University Faculty of Medicine, Department of Medical Biochemistry, İstanbul, Turkey Objective: Low glutamine levels have been shown in tumor environments for several cancer subtypes. Therefore, it has been suggested that cancer cells rewire their metabolism to adopt low nutrient levels for survival and proliferation. Although glutamine is a non-essential amino acid and can be synthesized de novo, many cancer cells including malignant hematopoietic cells have been indicated to be addicted to glutamine. This study aimed to investigate the proliferation of leukemia cell lines in glutamine-deprived conditions. Burcu Yücel, Saniye Ada. Leukemia Cells Resistant to Glutamine Deprivation Express Glutamine Synthetase Protein. . 2022; 39(1): 22-28 Sorumlu Yazar: Burcu Yücel, Türkiye |
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