. 2014; 31(1): 56-60 | DOI: 10.4274/Tjh.2013.0086 | |||
FIP1L1-PDGFRA Pozitif Kronik Eozinofilik Lösemi: İmatinib için Dramatik Yanıt ile Bir Düşük Yük Hastalığı-Güney Hindistan’dan 5 Olgu SunumuAnıl Kumar N.1, Vishwanath Sathyanarayanan1, Visweswariah Lakshmi Devi2, Namratha N. Rajkumar2, Umesh Das1, Sarjana Dutt3, Lakshmaiah K Chinnagiriyappa11Kidwai Memorial Institute Of Oncology, Department Of Medical Oncology, Karnataka, India2Kidwai Memorial Institute Of Oncology, Department Of Pathology, Karnataka, India 3Oncquest Laboratories Ltd., New Delhi, India AMAÇ: FIP1L1-PDGFRA rearranjmanı ilişkili eozinofili, kronik eozinofilik löseminin bir alt grubunu temsil eder ve etkilenen hastalar imatinib tedavisine duyarlıdır. Bu çalışma, şiddetli eozinofili ile başvuran 26 erişkin hastadan oluşan bir grupta FIP1L1-PDGFRA rearranjmanının klinikopatolojik ve genetik yaygınlığını, ve özelliklerini öğrenmek için yapıldı. FIP1L1-PDGFRA-Positive Chronic Eosinophilic Leukemia: A Low-Burden Disease with Dramatic Response to Imatinib - A Report of 5 Cases from South IndiaAnıl Kumar N.1, Vishwanath Sathyanarayanan1, Visweswariah Lakshmi Devi2, Namratha N. Rajkumar2, Umesh Das1, Sarjana Dutt3, Lakshmaiah K Chinnagiriyappa11Kidwai Memorial Institute Of Oncology, Department Of Medical Oncology, Karnataka, India2Kidwai Memorial Institute Of Oncology, Department Of Pathology, Karnataka, India 3Oncquest Laboratories Ltd., New Delhi, India OBJECTIVE: Eosinophilia associated with FIP1L1-PDGFRA rearrangement represents a subset of chronic eosinophilic leukemia and affected patients are sensitive to imatinib treatment. This study was undertaken to learn the prevalence and associated clinicopathologic and genetic features of FIP1L1-PDGFRA rearrangement in a cohort of 26 adult patients presenting with profound eosinophilia (>1.5x109/L). Anıl Kumar N., Vishwanath Sathyanarayanan, Visweswariah Lakshmi Devi, Namratha N. Rajkumar, Umesh Das, Sarjana Dutt, Lakshmaiah K Chinnagiriyappa. FIP1L1-PDGFRA-Positive Chronic Eosinophilic Leukemia: A Low-Burden Disease with Dramatic Response to Imatinib - A Report of 5 Cases from South India. . 2014; 31(1): 56-60 Sorumlu Yazar: Anıl Kumar N., India |
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