. 2016; 33(2): 141-147 | DOI: 10.4274/tjh.2015.0193 | |||
Mantle Hücreli Lenfoma Hastalarında Rho-Kinaz Ekspresyonları ve Polimorfizmlerinin AraştırılmasıDidar Yanardağ Açık1, Mehmet Yılmaz1, İbrahim Sarı2, Serdar Öztuzcu3, Zeynel A. Sayıner4, Salih Subari4, Abdullah T. Demiryürek51Gaziantep University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Gaziantep, Turkey2Gaziantep University Faculty of Medicine, Department of Pathology, Gaziantep, Turkey 3Gaziantep University Faculty of Medicine, Department of Medical Biology, Gaziantep, Turkey 4Gaziantep University Faculty of Medicine, Department of Internal Medicine, Gaziantep, Turkey 5Gaziantep University Faculty of Medicine, Department of Medical Pharmacology, Gaziantep, Turkey GİRİŞ ve AMAÇ: Mantle hücreli lenfoma (MHL) siklin D1’in aşırı ekspresyonuyla karakterize B-hücreli Hodgkin dışı lenfomanın nadir fakat agresif bir şeklidir. İntraselüler sinyal enzimi olan Rho-kinaz (ROCK), hücre migrasyonu, proliferasyonu, farklılaşması yanında tümör gelişimi ve metastazına da katkıda bulunur. Fakat MHL hastalarında ROCK gen ve protein ekspresyonları veya polimorfizmleri araştırılmamıştır. Bu çalışmanın amacı, MHL hastalarında ROCK gen ve protein ekspresyonlarının rolünü araştırmaktı. Biz bu çalışmada ROCK2 gen polimorfizmleri de araştırdık. Investigation of Rho-Kinase Expressions and Polymorphisms in Mantle Cell Lymphoma PatientsDidar Yanardağ Açık1, Mehmet Yılmaz1, İbrahim Sarı2, Serdar Öztuzcu3, Zeynel A. Sayıner4, Salih Subari4, Abdullah T. Demiryürek51Gaziantep University Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Gaziantep, Turkey2Gaziantep University Faculty of Medicine, Department of Pathology, Gaziantep, Turkey 3Gaziantep University Faculty of Medicine, Department of Medical Biology, Gaziantep, Turkey 4Gaziantep University Faculty of Medicine, Department of Internal Medicine, Gaziantep, Turkey 5Gaziantep University Faculty of Medicine, Department of Medical Pharmacology, Gaziantep, Turkey INTRODUCTION: Mantle cell lymphoma (MCL) is a rare but aggressive form of B-cell non-Hodgkin lymphoma characterized by excessive expression of cyclin D1. Intracellular signaling enzyme Rho-kinase (ROCK) can contribute to cellular migration, proliferation, and differentiation, as well as tumor development and metastasis. However, ROCK gene and protein expressions or polymorphisms have never been investigated in MCL patients. The purpose of this study was to investigate the role of ROCK gene and protein expressions in MCL patients. We also examined ROCK2 gene polymorphisms in this study. Didar Yanardağ Açık, Mehmet Yılmaz, İbrahim Sarı, Serdar Öztuzcu, Zeynel A. Sayıner, Salih Subari, Abdullah T. Demiryürek. Investigation of Rho-Kinase Expressions and Polymorphisms in Mantle Cell Lymphoma Patients. . 2016; 33(2): 141-147 Sorumlu Yazar: Didar Yanardağ Açık, Türkiye |
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