. 2007; 24(4): 155-163 | |||
The effects of platelet receptor GPIIb/IIIa polymorphism (Leu Pro33) on the receptor expression and platelet aggregation in patients with ischaemic strokeEndre Pongrácz1, Katalin Schweitzer2, József Furész2, János Fent2, Attila Tordai3, Zoltán Nagy41Department Of Neurology, Stroke Unit, Central Hospital Of Home Office, Budapest, Hungary2Department Of Pathophisiology, Institute Of Health Protection, Hungarian Defence Forces, Budapest, Hungary 3Department Of Molecular Genetics, National Institute Of Haemathology, Budapest, Hungary 4Department Of Vascular Neurology, National Stroke Centre, Semmelweis University, Budapest, Hungary Platelet hyperaggregation in ischaemic stroke patients is a proven finding, and associated with increased expression of the platelet surface GPIIb/IIIa receptor. The polymorphism occurs at nucleotide position 1565 of the GPIIIa gene resulting a 33Leu-Pro change. Data are conflicting regarding the abnormal function of the PlA1/A2 receptor in stroke. The aim of the study was to address the difference of platelet receptor function in ischemic stroke patients with the wild PlA1/A1 and heterozygous PlA1/A2 genotype. A total of 51 patients with PA1/A1 and 54 patients with PlA1/A2 genotypes were enrolled. Polymerase chain Endre Pongrácz, Katalin Schweitzer, József Furész, János Fent, Attila Tordai, Zoltán Nagy. The effects of platelet receptor GPIIb/IIIa polymorphism (Leu Pro33) on the receptor expression and platelet aggregation in patients with ischaemic stroke. . 2007; 24(4): 155-163 Sorumlu Yazar: Endre Pongrácz, Hungary |
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